Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE To evaluate the efficacy of using a CRISPR/Cas-mediated strategy to correct a common high-risk allele that is associated with age-related macular degeneration (AMD; rs1061170; NM_000186.3:c.1204T>C; NP_000177.2:p.His402Tyr) in the complement factor H <i>(CFH)</i> gene. 30996586 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE The aim of this study was to compare the functional and morphological 1-year evolution of patients with exudative AMD treated with antivascular endothelial growth factor (VEGF) drugs with the CFH Y402H polymorphism in the Brazilian population. 28641277 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 Biomarker disease BEFREE Genetic changes in and around several complement system genes, including the CFH, contribute to the formation of drusen and progression of AMD. 31456517 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 Biomarker disease BEFREE Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration. 30705315 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE Associations of microRNAs, Angiogenesis-Regulating Factors and CFH Y402H Polymorphism-An Attempt to Search for Systemic Biomarkers in Age-Related Macular Degeneration. 31731799 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE When adjusting for age, sex, ARMS2 and CFH risk alleles, and examination phase, the ox-LDL at the beginning of a period was not statistically significantly associated with the incidence of any AMD (hazard ratio per 10 U/L ox-LDL was 1.03, 95% confidence interval 0.98,1.09). 30572074 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 Biomarker disease BEFREE Complement factor H‑related 3 (CFHR3) belongs to the human factor H protein family and is associated with various human diseases, including nephropathy, age‑related macular degeneration and atypical hemolytic uremic syndrome. 31524260 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE The association between complement factor H rs1061170 polymorphism and age-related macular degeneration: a comprehensive meta-analysis stratified by stage of disease and ethnicity. 30280493 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE A human induced pluripotent stem cell (hiPSC) line was derived from peripheral blood mononuclear cells (PBMCs) from a patient with a clinical diagnosis of dry AMD carrying the CFH Y402H polymorphism. 31176916 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE CFH and ARMS2 risk alleles do not modify the response to the AREDS2 nutrient supplements with respect to the progression to late AMD (GA and neovascular AMD). 31358387 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 Biomarker disease BEFREE We report a novel association wherein older adults with high-risk ARMS2 and CFH genotypes are more likely to demonstrate delayed RMDA, the first functional biomarker for incident early AMD. 30389424 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE Molecular Mechanisms of Macular Degeneration Associated with the Complement Factor H Y402H Mutation. 30616835 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 AlteredExpression disease BEFREE While CFH activity levels were not correlated with AMD, a significant interaction was evident between patient age and CFH activity. 30820144 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 AlteredExpression disease BEFREE Levels of CFB and CFH were significantly increased in the aqueous humour of neovascular AMD patients (p = 0.023 and p = 0.018, respectively). 31267090 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE A significant genotype and variant allele association was found of rs10490924 in ARMS2/HTRA1 with wet AMD, while the SNPs in CFH, CFB, and C3 were not associated with AMD in the current Pakistani cohort. 30895599 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE The major risk to develop AMD is the Y402H polymorphism of complement factor H (CFH). 31554875 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE Comparison of ARMS2/LOC387715 A69S and CFH Y402H risk effect in wet-type age-related macular degeneration: a meta-analysis. 29423786 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE However, weak correlations between 10 SNPs (CFH rs1329428 TT genotype, CFH rs3753394 CC genotype and T allele, CFH rs1410996 AA genotype, CFH rs800292 AA genotype, CFH rs800292 A allele, VEGF rs833061 TT genotype and C allele, VEGF rs2010963 CG genotype, VEGFR2 rs1531289 TT genotype, ARMS2 rs10490924 TT genotype, KCTD10 rs238104 GC genotype, rs1531289 T allele and ARMS2 rs10490924 T allele) and AMD were shown. 30696427 2019
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE Complement activation plays a significant role in age-related macular degeneration (AMD) pathogenesis, and polymorphisms interfering with factor H (fH) function, a complement alternative pathway (AP) inhibitor, are associated with increased AMD risk. 29234687 2018
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE PTX3 was found to be present in the macula of donor eyes and the AMD-associated Y402H polymorphism altered the binding of FHL-1 to PTX3. 29374201 2018
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE Genome-Wide Association Study Reveals Variants in CFH and CFHR4 Associated with Systemic Complement Activation: Implications in Age-Related Macular Degeneration. 29398083 2018
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE Association of risk genotypes of ARMS2/LOC387715 A69S and CFH Y402H with age-related macular degeneration with and without reticular pseudodrusen: a meta-analysis. 28593728 2018
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE After adjusting for age, sex, smoking, energy intake, fish consumption, and AMD risk alleles (complement factor H and age-related maculopathy susceptibility-2 single nucleotide polymorphisms), participants in the third quartile compared with those in the first quartile (reference group) of total nitrate and total vegetable nitrate intake had reduced risk of incident early AMD: odds ratio (OR) 0.61 (95% CI 0.41 to 0.90) and OR 0.65 (95% CI 0.44 to 0.96), respectively. 30342988 2018
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE This study suggests a high risk for incident early AMD in individuals with high plasma high-density lipoprotein cholesterol levels while confirming the high risk for progression from early to advanced AMD in heavy smokers and carriers of CFH Y402H at-risk genotypes. 29596588 2018
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.500 GeneticVariation disease BEFREE Older age and the presence of CFH and ARMS2 risk alleles are two main risk factors associated with the prevalence of AMD in the TILDA cohort. 29453225 2018