Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 718
Gene Symbol: C3
C3
0.700 Biomarker disease BEFREE Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Randomized Phase 2 Trial. 31474439 2020
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE Increased risk of RPD formation is conveyed by genetic variants known to increase risk of AMD development, including complement factor H, age-related maculopathy susceptibility 2, and high-temperature requirement A serine peptidase 1; however, to date, no genetic factor has been found to predispose to RPD independent of those that carry risks for AMD. 30298528 2019
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE Before the AMD clinical phenotype is present, those showing normal macular health with the ARMS2 A69S allele demonstrate delayed RMDA. 30389424 2019
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.700 GeneticVariation disease BEFREE Stargardt disease (On-Line Mendelian Inheritance In Man 242000, STGD1) is the most common inherited macular dystrophy. 31318848 2019
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE CFH and ARMS2 risk alleles do not modify the response to the AREDS2 nutrient supplements with respect to the progression to late AMD (GA and neovascular AMD). 31358387 2019
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE However, weak correlations between 10 SNPs (CFH rs1329428 TT genotype, CFH rs3753394 CC genotype and T allele, CFH rs1410996 AA genotype, CFH rs800292 AA genotype, CFH rs800292 A allele, VEGF rs833061 TT genotype and C allele, VEGF rs2010963 CG genotype, VEGFR2 rs1531289 TT genotype, ARMS2 rs10490924 TT genotype, KCTD10 rs238104 GC genotype, rs1531289 T allele and ARMS2 rs10490924 T allele) and AMD were shown. 30696427 2019
Entrez Id: 629
Gene Symbol: CFB
CFB
0.700 GeneticVariation disease BEFREE A significant genotype and variant allele association was found of rs10490924 in ARMS2/HTRA1 with wet AMD, while the SNPs in CFH, CFB, and C3 were not associated with AMD in the current Pakistani cohort. 30895599 2019
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE Association of rs10490924 in ARMS2/HTRA1 with age-related macular degeneration in the Pakistani population. 30895599 2019
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.700 GeneticVariation disease BEFREE Stargardt disease (STGD1, OMIM 248200) is a common hereditary juvenile or early adult onset macular degeneration. 30563929 2019
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.700 GeneticVariation disease BEFREE Antioxidant Saffron and Central Retinal Function in ABCA4-Related Stargardt Macular Dystrophy. 31618812 2019
Entrez Id: 629
Gene Symbol: CFB
CFB
0.700 GeneticVariation disease BEFREE Collectively, we demonstrated that the complement factor B genes rs641153 and rs4151667, but not rs1048709, rs2072633, rs12614, were associated with the susceptibility of age-related macular degeneration and might play predictive roles in future age-related macular degeneration diagnosis. 30974970 2019
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.700 Biomarker disease BEFREE Generation of the induced pluripotent stem cell line from a patient with autosomal recessive ABCA4-mediated Stargardt Macular Dystrophy. 30634128 2019
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE Sub-analysis demonstrated that women with ARMS2 A69S polymorphisms had a stronger risk for early AMD (OR: 3.25, 95% CI: 2.10-5.04) than men (OR: 1.65, 95% CI: 1.02-2.69). 29335418 2018
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE Blood samples from all subjects were genotyped for major age-related macular degeneration (AMD)-associated single nucleotide polymorphisms (SNPs) the major AMD-associated SNPs; CFH Y402H rs1061170, CFH rs800292" genes_norm="3075;5362">I62V rs800292, ARMS2 rs10490924" genes_norm="387715">A69S rs10490924. 30596689 2018
Entrez Id: 718
Gene Symbol: C3
C3
0.700 GeneticVariation disease GWASCAT Genome-wide analysis of disease progression in age-related macular degeneration. 29346644 2018
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE Among different genotype combinations ARMS2-CFH and CFH-C3 combinations have the most significant levels of synergism and C3-CFI combination has the most significant level of antagonism in AMD patients. 29087762 2018
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE In this post hoc analysis of cross-sectional data from US participants in the Comparison of AMD Treatments Trials, genotyping was performed in 835 participants with TaqMan assays for the SNPs rs1061170 (Y402H variant in CFH), rs800292 (rs800292" genes_norm="3075">I62V variant in CFH), rs10490924 (rs10490924;s10490924" genes_norm="387715;717">A69S variant in ARMS2), rs11200638 (HTRA1), rs547154 (C2), rs2230199 (rs2230199" genes_norm="5654;718">R102G variant in C3), rs10468017 (LIPC), and rs4151667 (L9H variant in CFB). 29801032 2018
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE Age and the T allele of ARMS2 A69S are the risk factors requiring retreatments, leading to poor visual change in eyes with exudative AMD following the initial 3-monthly IVR. 29045945 2018
Entrez Id: 629
Gene Symbol: CFB
CFB
0.700 GeneticVariation disease BEFREE Studies that investigated associations between C2 (rs547154 and rs9332739), C3 (rs1047286), CFB (rs4151667 and rs641153), and CFH (rs551397 and rs2274700) polymorphisms and AMD were identified by searching PubMed, EMBASE, Web of Science, and Cochrane Library databases for articles published prior to January 1, 2018. 30179527 2018
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.700 GeneticVariation disease BEFREE Stargardt disease, type 1 (STGD1) or macular degeneration with flecks, STGD1 represents a disease with early onset, central visual impairment, frequent appearance of yellowish flecks and mutations in the ATP-binding cassette subfamily A, member 4 (ABCA4) gene. 29461686 2018
Entrez Id: 629
Gene Symbol: CFB
CFB
0.700 GeneticVariation disease BEFREE We identified four previously reported susceptibility loci showing genome-wide significant association with AMD progression: ARMS2-HTRA1 (P = 8.1 × 10-43), CFH (P = 3.5 × 10-37), C2-CFB-SKIV2L (P = 8.1 × 10-10) and C3 (P = 1.2 × 10-9). 29346644 2018
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE This interaction is opposite in direction to that observed in AMD, where patients with 2 CFH and 0 ARMS2 risk alleles had increased progression to neovascular AMD if treated with 80 mg/day of zinc. 30320589 2018
Entrez Id: 387715
Gene Symbol: ARMS2
ARMS2
0.700 GeneticVariation disease BEFREE Incident early AMD was associated with cardiovascular disease history (HR 1.59, 95% CI 1.04-2.45), underweight body mass index (BMI) (HR 3.12, 95% CI 1.37-7.14) (BMI of <18.5 vs 18.51-25 kg/m2), heavy alcohol drinking (HR 3.14 95% CI 1.25-7.89) and ARMS2 rs3750847 homozygous genetic loci carrier (HR 2.52, 95% CI 1.59-3.99). 29891972 2018
Entrez Id: 629
Gene Symbol: CFB
CFB
0.700 GeneticVariation disease BEFREE In this post hoc analysis of cross-sectional data from US participants in the Comparison of AMD Treatments Trials, genotyping was performed in 835 participants with TaqMan assays for the SNPs rs1061170 (Y402H variant in CFH), rs800292 (rs800292" genes_norm="3075">I62V variant in CFH), rs10490924 (rs10490924;s10490924" genes_norm="387715;717">A69S variant in ARMS2), rs11200638 (HTRA1), rs547154 (C2), rs2230199 (rs2230199" genes_norm="5654;718">R102G variant in C3), rs10468017 (LIPC), and rs4151667 (L9H variant in CFB). 29801032 2018
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.700 Biomarker disease BEFREE Early Patterns of Macular Degeneration in ABCA4-Associated Retinopathy. 29310964 2018