Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group HPO
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 AlteredExpression group BEFREE <b>Results:</b> Plasma α-synuclein level was significantly increased in patients with PD and APS when compared with controls and FTD without parkinsonism (<i>p</i> < 0.01). 29755341 2018
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 AlteredExpression group BEFREE 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exacerbates mitochondrial impairment and α-synuclein expression leading to Parkinsonism. 31732923 2020
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Parkinsonism due to A53E α-synuclein gene mutation: Clinical, genetic, epigenetic, and biochemical features. 30423204 2018
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Parkinsonism-linked mutations in alanine and glutamic acid residues of the pre-synaptic protein α-Synuclein (α-Syn) affect specific tertiary interactions essential for stability of the native state and make it prone to more aggregation. 31385584 2019
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE NACP/alpha-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: double-immunolabeling fluorescence and electron microscopic studies. 10963357 2000
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE Alpha-synuclein is involved in a rare dominant form of familial PD with dopa-responsive parkinsonism features and Lewy body-positive pathology. 11037196 2000
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 PosttranslationalModification group BEFREE Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism. 17077307 2006
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism. 19576930 2009
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Alpha-synuclein gene (SNCA) mutations cause familial Parkinsonism but the role of SNCA variability in idiopathic Parkinson's disease (PD) remains incompletely defined. 19890971 2009
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Alpha-synuclein (SNCA) is a major risk gene for Parkinson's disease (PD), and increased SNCA gene dosage results in a parkinsonian syndrome in affected families. 20445061 2010
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE Alpha-synuclein (SNCA) is a major risk gene for Parkinson's disease (PD) and increased SNCA gene dosage results in a parkinsonian syndrome in affected families. 22617348 2012
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE α-Synuclein gene (SNCA) multiplications cause familial parkinsonism and allele-length polymorphisms within the SNCA dinucleotide repeat REP1 increase the risk for developing Parkinson's disease (PD). 24656894 2014
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism. 29310663 2018
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE A 6.4 Mb duplication of the α-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations. 25003242 2014
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE A Meta-Analysis of α-Synuclein Multiplication in Familial Parkinsonism. 30619023 2018
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE A missense mutation of the alpha-synuclein gene has been associated with parkinsonism in a large Italian kindred. 9566408 1998
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE Accumulation of the synaptic protein alpha-synuclein (alpha-syn) is a hallmark of Parkinson's disease (PD) and Lewy body disease (LBD), a heterogeneous group of disorders with dementia and parkinsonism, where Alzheimer's disease and PD interact. 19864570 2009
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE Ample evidence has suggested that extracellular α-synuclein aggregates would play key roles in the pathogenesis and progression of Parkinsonian disorders (PDs). 28297586 2017
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE An analysis of 43 tagging single nucleotide polymorphisms across the SNCA locus shows 2 distinct association profiles for symptoms of parkinsonism and/or dementia, respectively, toward the 3' or the 5' of the SNCA gene. 27091628 2016
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Clinical course of the first Asian family with Parkinsonism related to SNCA triplication. 20818659 2010
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications. 14755720 2004
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE CSF a-synuclein (α-syn) has emerged as a promising biomarker in patients with Parkinsonism. 29111028 2017
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE Disorders characterized by α-synuclein (α-syn) accumulation, Lewy body formation and parkinsonism (and in some cases dementia) are collectively known as Lewy body diseases. 23254192 2013
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Disorders with progressive accumulation of α-synuclein (α-syn) are a common cause of dementia and parkinsonism in the aging population. 28476636 2017