Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group HPO
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 AlteredExpression group LHGDN SNCA dosage is responsible for parkinsonism, autonomic dysfunction, and dementia observed within each family/expression of wild-type alpha-synuclein results in parkinsonism. 18571778 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group LHGDN study identified a new family with SNCA duplication who developed parkinsonism, visual hallucination, and cognitive fluctuation 18852445 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group LHGDN Pathologically confirmed Lewy body disease clinically characterized by progressive parkinsonism and cognitive dysfunction is caused by SNCA duplication 18413475 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group CTD_human The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity. 22319455 2012
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group CTD_human shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model. 26075822 2015
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group CTD_human α-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced α-synuclein and PINK1 levels after rotenone treatment. 20464527 2011
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group CTD_human Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells. 26558463 2016
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group CTD_human Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: implication in autosomal recessive juvenile parkinsonism. 23046578 2013
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group CTD_human The behavioural and neuropathological impact of intranigral AAV-α-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats. 23295396 2013
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group CTD_human Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions. 27324791 2017
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE Disorders characterized by α-synuclein (α-syn) accumulation, Lewy body formation and parkinsonism (and in some cases dementia) are collectively known as Lewy body diseases. 23254192 2013
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication. 14736756 2004
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE The alpha-synuclein gene (SNCA) multiplication causes autosomal dominant Parkinson Disease (PD): triplication is associated with early-onset rapidly progressing parkinsonism with a strong likelihood of developing dementia, while duplication is associated with a less severe phenotype similar to idiopathic PD. 19833540 2010
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE NACP/alpha-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: double-immunolabeling fluorescence and electron microscopic studies. 10963357 2000
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE The discoveries of genes related to hereditary forms of parkinsonism (PARK1, PARK2, PARK6, PARK7 and PARK8) have increased our understanding either of distinct subtypes of clinical expression in PD or its etiology. 17388981 2007
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE We found that over half of the reported cases with SNCA duplication had early-onset parkinsonism and non-motor features, such as dysautonomia, rapid eye movement sleep behavior disorder (RBD), hallucinations (usually visual) and cognitive deficits leading to dementia. 26350119 2016
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE We also detected strong associations at SNCA on 4q22 (P = 7.35 x 10(-17)) and LRRK2 on 12q12 (P = 2.72 x 10(-8)), both of which are implicated in autosomal dominant forms of parkinsonism. 19915576 2010
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE The SNCA duplication case presented with a clinical phenotype of frontotemporal dementia with marked behavioural changes, pyramidal signs, postural hypotension and transiently levodopa responsive parkinsonism. 26306801 2016
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE We describe an Australian family of Greek origin with a parkinsonian syndrome and an Ala53Thr alpha-synuclein gene mutation. 11261505 2001
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Mutations and multiplications of alpha-synuclein (α-syn) cause familial PD, and chronic manganese (Mn) exposure can produce an encephalopathy with signs of parkinsonism. 21333719 2011
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Mutations in the alpha-synuclein gene are responsible for rare familial cases of parkinsonism, and polymorphisms in the promoter region of this gene confer a higher susceptibility to idiopathic PD. 20430055 2010
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Recently, genomic multiplications of alpha-synuclein gene (SNCA) have been reported to cause hereditary early-onset parkinsonism. 16358335 2006
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE α-Synuclein gene (SNCA) multiplications cause familial parkinsonism and allele-length polymorphisms within the SNCA dinucleotide repeat REP1 increase the risk for developing Parkinson's disease (PD). 24656894 2015
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE α-Synuclein and Parkinsonism: Updates and Future Perspectives. 28324300 2017