Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group HPO
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE A missense mutation of the alpha-synuclein gene has been associated with parkinsonism in a large Italian kindred. 9566408 1998
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 AlteredExpression group BEFREE In conclusion, reduced alpha-synuclein gene expression may be important in the pathogenesis of parkinsonism. 10482268 1999
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE NACP/alpha-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: double-immunolabeling fluorescence and electron microscopic studies. 10963357 2000
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE PET studies of parkinsonism associated with mutation in the alpha-synuclein gene. 10599788 2000
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE We describe an Australian family of Greek origin with a parkinsonian syndrome and an Ala53Thr alpha-synuclein gene mutation. 11261505 2001
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE The fact that Lewy bodies stain strongly with antibodies to asynuclein and that mutations in the alpha-synuclein gene lead to syndromes in which parkinsonism and dementia occur gives us important clues regarding the biologic processes leading to disease. 12489918 2003
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE In this study no one of our 85 patients of Serbian origin with young-onset (</= 45 years) dopa-responsive parkinsonism (YOP), previously proved negative for PARK1 and PARK2 mutations, had either spinocerebellar ataxia type 2 (SCA2) or SCA3 mutation. 12940846 2003
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication. 14736756 2004
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Mutations in the alpha-synuclein (alpha-syn) gene are responsible for a rare familial parkinsonism syndrome, a finding that has led to extensive characterization of altered alpha-syn structure in sporadic Parkinson's disease (PD) and other neurodegenerative disorders. 15144854 2004
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE These findings prompted us to screen for multiplication of the SNCA locus in nine families in whom parkinsonism segregates as an autosomal dominant trait. 15451224 2004
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Recently, genomic multiplications of alpha-synuclein gene (SNCA) have been reported to cause hereditary early-onset parkinsonism. 16358335 2006
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE We examined 7 patients from a family harboring a novel mutation in the alpha-synuclein gene (E46K) that segregated with a phenotype of parkinsonism and dementia with Lewy bodies. 16001411 2006
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE The discoveries of genes related to hereditary forms of parkinsonism (PARK1, PARK2, PARK6, PARK7 and PARK8) have increased our understanding either of distinct subtypes of clinical expression in PD or its etiology. 17388981 2007
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE The genetic basis for familial parkinsonism is an SNCA-MMRN11 multiplication, but whereas SNCA-MMRN1 duplication in the Swedish proband (Branch J) leads to late-onset autonomic dysfunction and parkinsonism, SNCA-MMRN1 triplication in the Swedish American family (Branch I) leads to early-onset Parkinson disease and dementia. 17251522 2007
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Since the discovery in 1997 of the first heritable form of parkinsonism that could be linked to a mutation in a single gene, SNCA, many more genetic leads have followed (Parkin, DJ-1, PINK1, LRRK2, to name a few); these have provided us with many molecular clues to better explore the etiology of parkinsonism and have led to the dismantling of many previously held dogmas about Parkinson disease (PD). 17761553 2007
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Genetic variation of the alpha-synuclein gene (SNCA) is known to cause familial parkinsonism, however the role of SNCA variants in sporadic Parkinson's disease (PD) remains elusive. 17531291 2007
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 AlteredExpression group LHGDN SNCA dosage is responsible for parkinsonism, autonomic dysfunction, and dementia observed within each family/expression of wild-type alpha-synuclein results in parkinsonism. 18571778 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group LHGDN study identified a new family with SNCA duplication who developed parkinsonism, visual hallucination, and cognitive fluctuation 18852445 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE We hypothesize dysregulated expression of wild-type alpha-synuclein results in parkinsonism and may explain the recent association of common SNCA variants in sporadic Parkinson's disease. 18571778 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Point mutations, duplications and triplications in the alpha-synuclein gene cause a rare dominant form of PS in families. 18787878 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE We screened 1,106 patients with parkinsonism (PD = 906, MSA = 200) for SNCA multiplication by multiplex PCR. 17625105 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Patients homozygous and heterozygous for SNCA duplication in a family with parkinsonism and dementia. 18413475 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE With the discovery of missense and multiplication mutations in the alpha-synuclein gene (SNCA) in familial parkinsonism, Lewy inclusions were found to stain intensely with antibodies raised against the protein. 18366718 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group LHGDN Pathologically confirmed Lewy body disease clinically characterized by progressive parkinsonism and cognitive dysfunction is caused by SNCA duplication 18413475 2008