Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group LHGDN The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval. 14691730 2004
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group LHGDN Hence, LRRK2 may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. 15541309 2004
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE Hence, LRRK2 may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. 15541309 2004
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE In summary, our study demonstrates that LRRK2 G2019S accounts for parkinsonism in several families within Europe and North America. 15726496 2005
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Several pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2; PARK8) gene recently have been identified in familial and sporadic parkinsonism. 15852371 2005
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family. 15880653 2005
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Recently, pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified in familial Parkinsonism. 16087219 2005
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE To identify novel LRRK2 mutations, we have sequenced 100 affected probands with family history of parkinsonism. 16172858 2005
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Multiple mutations in the gene for the leucine-rich repeat kinase (LRRK2) cause autosomal dominant late-onset parkinsonism (PARK8). 16254973 2005
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE These data suggest that parkinsonism caused by mutations in LRRK2 is likely to represent the commonest locus for autosomal dominant Parkinson's disease with a phenotype, pathology and in vivo imaging similar to idiopathic, late-onset Parkinson's disease. 16272164 2005
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE Understanding the molecular function of the LRRK2 protein and its associated pathways might elucidate the switch between Lewy body pathology and neurofibrillary tangles, and holds promise for prospective therapeutics that might slow or halt progression of many forms of parkinsonism. 16406842 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE The Lrrk2 kinase domain G2019S substitution is the most common genetic basis of familial and sporadic parkinsonism. 16437559 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE The third patient was characterized by parkinsonism without Lewy bodies but demonstrated dystrophic neurites in the substantia nigra intensely stained for Lrrk2. 16437584 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Moreover, mutations in LRRK2 known to cause parkinsonism are associated not only with dopaminergic neuronal degeneration, but also with the accumulation of synuclein, tau, neither, or both proteins. 16489609 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Therefore, the LRRK2 mutation has a relatively high frequency in the AJ population, is not fully penetrant for parkinsonism in the elderly, and does not appear to be commonly associated with late-onset dementia. 16632201 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE Pathogenic mutations in the leucine-rich repeat kinase 2 gene (LRRK2; PARK8) have been implicated in autosomal dominant, late-onset parkinsonism. 16643318 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE These findings suggest that GBA and LRRK2 mutations are discrete risk factors for parkinsonism in both Ashkenazi Jewish and non-Jewish subjects. 16781064 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group LHGDN These findings suggest that GBA and LRRK2 mutations are discrete risk factors for parkinsonism in both Ashkenazi Jewish and non-Jewish subjects. 16781064 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group LHGDN This review summarizes the current knowledge on the contribution of LRRK2 mutations in understanding parkinsonism. 16822348 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE This review summarizes the current knowledge on the contribution of LRRK2 mutations in understanding parkinsonism. 16822348 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE However we can not rule out other genetic variation at the LRRK2 locus may play a role in parkinsonian disorders with amyotrophic lateral sclerosis and may be considered candidates for genetic screening. 16865326 2007
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE The underlying disease mechanisms of LRRK2 G2019S-associated parkinsonism are similar to those of typical Parkinson disease. 16966501 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE This short review highlights the clinical and pathologic features in LRRK2-associated parkinsonism. 17017533 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 Biomarker group BEFREE Hence, LRRK2 may be central to the pathogenesis of several major neurodegenerative disorders associated with parkinsonism. 17017534 2006
Entrez Id: 120892
Gene Symbol: LRRK2
LRRK2
0.400 GeneticVariation group BEFREE We have identified Family SK where Lrrk2 G2019S segregates with slowly progressive parkinsonism and the affected proband has tau-immunopositive neurofibrillary tangle pathology. 17060589 2006