Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE NMR spectroscopy demonstrates that Parkinsonism-linked mutations greatly perturb specific tertiary interactions essential for the native state of alpha-synuclein. 16020550 2005
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Recently, genomic multiplications of alpha-synuclein gene (SNCA) have been reported to cause hereditary early-onset parkinsonism. 16358335 2006
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE The presence of alpha-synuclein Lewy body pathology is used to distinguish Parkinson's disease from parkinsonism, for which a broader spectrum of neuropathologies, including tau-immunopositive neurofibrillary tangles and ubiquitin inclusions, might accompany nigral neuronal loss. 16406842 2006
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 PosttranslationalModification group BEFREE We show here, in the MPP+ (1-methyl-4-phenylpyridinium ion) cell model of parkinsonism, a time- and dose-dependent increase in the hyperphosphorylation of Tau at pSer396/404 (PHF-1-reactive Tau, p-Tau), concomitant with increased accumulation of alpha-Syn, upon treatment of cells with the neurotoxin. 17000465 2006
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 PosttranslationalModification group BEFREE Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism. 17077307 2006
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE The genetic basis for familial parkinsonism is an SNCA-MMRN11 multiplication, but whereas SNCA-MMRN1 duplication in the Swedish proband (Branch J) leads to late-onset autonomic dysfunction and parkinsonism, SNCA-MMRN1 triplication in the Swedish American family (Branch I) leads to early-onset Parkinson disease and dementia. 17251522 2007
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE However, the alpha-synuclein locus (SNCA) multiplication families have clinically displayed parkinsonism and autonomic dysfunction. 17291816 2007
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE The discoveries of genes related to hereditary forms of parkinsonism (PARK1, PARK2, PARK6, PARK7 and PARK8) have increased our understanding either of distinct subtypes of clinical expression in PD or its etiology. 17388981 2007
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Genetic variation of the alpha-synuclein gene (SNCA) is known to cause familial parkinsonism, however the role of SNCA variants in sporadic Parkinson's disease (PD) remains elusive. 17531291 2007
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Mutations in five causative genes combined [alpha-Synuclein (SNCA), Parkin, PTEN-induced kinase 1 (PINK1), DJ-1, Leucine-rich repeat kinase 2 (LRRK2)] account for 2-3% of all cases with classical parkinsonism, often clinically indistinguishable from idiopathic Parkinson's disease. 17620882 2007
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE We screened 1,106 patients with parkinsonism (PD = 906, MSA = 200) for SNCA multiplication by multiplex PCR. 17625105 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Since the discovery in 1997 of the first heritable form of parkinsonism that could be linked to a mutation in a single gene, SNCA, many more genetic leads have followed (Parkin, DJ-1, PINK1, LRRK2, to name a few); these have provided us with many molecular clues to better explore the etiology of parkinsonism and have led to the dismantling of many previously held dogmas about Parkinson disease (PD). 17761553 2007
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE With the discovery of missense and multiplication mutations in the alpha-synuclein gene (SNCA) in familial parkinsonism, Lewy inclusions were found to stain intensely with antibodies raised against the protein. 18366718 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Pathologically confirmed Lewy body disease clinically characterized by progressive parkinsonism and cognitive dysfunction is caused by SNCA duplication. 18413475 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group LHGDN Pathologically confirmed Lewy body disease clinically characterized by progressive parkinsonism and cognitive dysfunction is caused by SNCA duplication. 18413475 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 AlteredExpression group LHGDN Herein we characterize five families with parkinsonism that have been identified to harbor multiplication of the chromosomal 4q21 locus containing the alpha-synuclein gene (SNCA). 18571778 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Herein we characterize five families with parkinsonism that have been identified to harbor multiplication of the chromosomal 4q21 locus containing the alpha-synuclein gene (SNCA). 18571778 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE In a first feasibility study employing a novel ELISA, we found relatively low CSF alphaS concentrations in subjects with parkinsonism linked to synucleinopathy, PD and DLB. 18625222 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE Point mutations, duplications and triplications in the alpha-synuclein gene cause a rare dominant form of PS in families. 18787878 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE We hypothesize that the former pediatric disease, as well as the parkinsonism and dementia phenotypes, are associated with duplications, triplications and possibly higher-order multiplications of the alpha-synuclein (SNCA) gene. 18824390 2009
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group LHGDN Prominent psychiatric symptoms and glucose hypometabolism in a family with a SNCA duplication. 18852445 2008
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE Four of 264 families (1.5%) with typical ADPD carried duplications and 1 of 22 families (4.5%) with atypical AD parkinsonism carried a triplication of SNCA. 19139307 2009
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE Here, we investigated the kinase involved and show that the Tau-specific kinase, glycogen synthase kinase 3beta (GSK-3beta), is robustly activated in various MPP(+)/MPTP models of Parkinsonism (SH-SY5Y cotransfected cells, mesencephalic neurons, transgenic mice overexpressing alpha-Syn, and postmortem striatum of PD patients). 19369384 2009
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 GeneticVariation group BEFREE The clinical features of SNCA duplication include parkinsonism with or without dementia. 19562770 2009
Entrez Id: 6622
Gene Symbol: SNCA
SNCA
0.500 Biomarker group BEFREE Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism. 19576930 2009