Gene: PARK7 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker group BEFREE The Saccharomyces cerevisiae heat shock proteins Hsp31-34 are members of DJ-1/ThiJ/Pfpl superfamily that includes human DJ-1 (Park7), a protein involved in heritable Parkinsonism. 30578832 2019
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker group CTD_human Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells. 26558463 2015
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker group RGD Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. 24969022 2014
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group BEFREE Mutations in parkin/PARK2, PINK1 or DJ1/PARK7 may cause early-onset parkinsonism with a low risk for cognitive decline and a pathological process usually restricted to the brainstem. 23462481 2013
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker group CTD_human Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: implication in autosomal recessive juvenile parkinsonism. 23046578 2013
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker group RGD Rotenone-induced parkinsonism elicits behavioral impairments and differential expression of parkin, heat shock proteins and caspases in the rat. 22710069 2012
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Biomarker group BEFREE In three forms, caused by mutations in parkin (PARK2), PINK1 (PARK6), or DJ-1 (PARK7), the phenotype is usually characterized by levodopa-responsive parkinsonism without atypical features. 22166450 2012
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Therapeutic group RGD Protection against dopaminergic neurodegeneration in Parkinson's disease-model animals by a modulator of the oxidized form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7. 22041943 2011
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group BEFREE Mutations in the parkin, PINK1 and DJ-1 genes all result in recessive parkinsonism. 21317550 2011
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group BEFREE Clinical features and [11C]-CFT PET analysis of PARK2, PARK6, PARK7-linked autosomal recessive early onset Parkinsonism. 20607337 2011
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group BEFREE A variety of mutations in the gene encoding DJ-1 protein cause autosomal recessive early-onset parkinsonism. 20806408 2010
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group BEFREE Mutation analysis of Parkin, PINK1 and DJ-1 genes in Chinese patients with sporadic early onset parkinsonism. 20146068 2010
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group BEFREE Compound heterozygosity in DJ-1 gene non-coding portion related to parkinsonism. 18722801 2009
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group BEFREE In the latter case, mutations or changes in the protein DJ-1 have been reported to be associated with autosomal recessive, early-onset parkinsonism. 19425177 2009
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 Therapeutic group RGD DJ-1-binding compounds prevent oxidative stress-induced cell death and movement defect in Parkinson's disease model rats. 18373560 2008
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group BEFREE In rare incidences familial forms of early-onset parkinsonism occur, and when recessively inherited, cases are often explained by mutations in either the parkin (PARK2) or PINK1 (PARK6) gene or on exceptional occasions the DJ-1 (PARK7) or ATP13A2 (PARK9) gene. 19087301 2008
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group BEFREE Inherited mutations in PARK7, the gene encoding DJ-1, are associated with loss of protein function and early-onset parkinsonism. 16894167 2006
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group LHGDN [Mutation analysis of DJ1 gene in patients with autosomal recessive early-onset Parkinsonism]. 16331561 2005
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group BEFREE Loss-of-function mutations in the DJ-1 gene cause early-onset familial parkinsonism. 15721235 2005
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group LHGDN DJ-1 mutations are a rare cause of recessively inherited early onset parkinsonism mediated by loss of protein function. 14985393 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group BEFREE Recently, mutations in DJ-1 (PARK7) were described as a novel cause of early-onset parkinsonism. 15372597 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group BEFREE Mutations in the DJ-1 gene lead to autosomal recessive early-onset parkinsonism. 15565491 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group BEFREE The DJ-1 gene is associated with autosomal recessive early-onset Parkinsonism, most likely through its role in defense against oxidative stress. 15542239 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group LHGDN Mutant genes responsible for Parkinson's disease. 15018843 2004
Entrez Id: 11315
Gene Symbol: PARK7
PARK7 		0.600 GeneticVariation group BEFREE Here, we show that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism. 12446870 2003