| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | group | BEFREE | Cerebrospinal fluid and plasma levels of neurofilament light chain can distinguish CBS from Parkinson's disease but not from other atypical forms of Parkinsonism. | 31145128 | 2019 | ||||
|
0.080 | AlteredExpression | group | BEFREE | To investigate cerebrospinal fluid (CSF) levels of neurofilament light (NFL) protein, a marker of neuroaxonal degeneration, in control participants and patients with dementia, motor neuron disease, and parkinsonian disorders (determined by clinical criteria and autopsy), and determine its association with longitudinal cognitive decline. | 30508027 | 2019 | ||||
|
0.080 | Biomarker | group | BEFREE | To investigate the diagnostic value of serum neurofilament light chain (NFL) in patients with clear signs of parkinsonism but whose specific diagnosis was yet uncertain. | 30814322 | 2019 | ||||
|
0.080 | Biomarker | group | BEFREE | The cerebrospinal fluid (CSF) neurodegeneration biomarkers such as neurofilament light chain (NF-L), total tau (t-tau), and the tau pathology marker phosphorylated tau (p-tau) are related to mortality in other neurological disorders (eg, amyotrophic lateral sclerosis, Alzheimer's disease), but have not been investigated in this respect in parkinsonian disorders. | 31070772 | 2019 | ||||
|
0.080 | Biomarker | group | BEFREE | Plasma neurofilament light (NFL) has been proposed as a blood-based biomarker for neurodegeneration in Alzheimer's disease (AD) and parkinsonian disorders. | 30478269 | 2018 | ||||
|
0.080 | Biomarker | group | BEFREE | To determine if blood neurofilament light chain (NfL) protein can discriminate between Parkinson disease (PD) and atypical parkinsonian disorders (APD) with equally high diagnostic accuracy as CSF NfL, and can therefore improve the diagnostic workup of parkinsonian disorders. | 28179466 | 2017 | ||||
|
0.080 | Biomarker | group | BEFREE | Neurofilament light chain may also have a significant role in differentiating PD from other parkinsonisms. | 28604235 | 2017 | ||||
|
0.080 | AlteredExpression | group | LHGDN | CSF neurofilament light chain and tau differentiate multiple system atrophy from Parkinson's disease. | 16678934 | 2007 |