In addition, evaluation of LRRK1 variants in our large Lrrk2 p.G2019S-parkinsonism series from a Tunisian (n=145) identified a missense mutation (p.L416M) resulting in an average 6.2 years younger age at disease onset.
One study has examined LRRK1 in familial parkinsonism by complete sequencing of the gene, reporting 4 novel non-synonymous coding variants within the LRRK1 gene.