Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.100 GeneticVariation phenotype BEFREE A distinct MRD high-risk subgroup of IGH-V(D)J-germline ALL revealed frequent deletions of IKZF1 (n = 7/11) and the presence of genomic fusions (n = 10/11). 31784504 2019
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.100 GeneticVariation phenotype BEFREE Lower relapse-free survival at 7 years (RFS) was associated with IKZF1 intragenic deletions (P < 0·0001); P2RY8-CRLF2 gene fusion (P < 0·0004); Day 33 MRD>5 × 10<sup>-5</sup> (P < 0·0001) and High National Cancer Institute (NCI) risk (P < 0·0001). 29194562 2018
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.100 GeneticVariation phenotype BEFREE Using a standardized bioinformatics algorithm, we identified kinase and cytokine receptor rearrangements in the majority of ALL patients with high burden of postinduction MRD and enrichment of IKZF1 mutation or deletion (IKZF1(del) ). 27007619 2016
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.100 GeneticVariation phenotype BEFREE The combination of IKZF1 deletion and p210 BCR-ABL1 (p < 0.0001), high white blood cell count (p = 0.021), and minimal residual disease (p = 0.013) were associated with worse disease-free survival. 26892479 2016
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.100 Biomarker phenotype BEFREE Importantly, neither MRD nor WBC count predicted events in the ∆IKZF1-positive cases. 26018335 2015
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.100 GeneticVariation phenotype BEFREE Within the limitation of sample size, however, considering both the negative impact of IKZF1 deletions on MRD kinetics and a trend for relationship between IKZF1 deletions and relapse in early-stable molecular responders, IKZF1 deletions may have a potentially additive effect on unfavorable prognosis in a specific MRD-based subgroup of adult Ph-positive ALL transplants. 25501350 2015
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.100 GeneticVariation phenotype BEFREE A higher specific hazard of relapse was independently associated with postinduction MRD level ≥10(-4) and unfavorable genetic characteristics (ie, MLL gene rearrangement or focal IKZF1 gene deletion in BCP-ALL and no NOTCH1/FBXW7 mutation and/or N/K-RAS mutation and/or PTEN gene alteration in T-cell ALL). 24740809 2014
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.100 GeneticVariation phenotype BEFREE Both the BCR-ABL1-like signature and IKZF1 deletions were prognostic features independent of conventional prognostic markers in a multivariate model, and both remained prognostic among cases with intermediate minimal residual disease. 23974192 2013
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.100 GeneticVariation phenotype BEFREE In multivariate analysis, which included ALL IC risk criteria, flow-cytometric MRD and IKZF1 alterations, day 15 MRD and IKZF1 deletion status displayed an independent prognostic impact. 22997141 2013
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.100 GeneticVariation phenotype BEFREE Breakpoint-specific multiplex polymerase chain reaction allows the detection of IKZF1 intragenic deletions and minimal residual disease monitoring in B-cell precursor acute lymphoblastic leukemia. 23065506 2013
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.100 Biomarker phenotype BEFREE Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study. 22368272 2012
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.100 Biomarker phenotype BEFREE Importantly, whereas MRD and IKZF1 status alone identified only 46 and 54% of the relapses, respectively, their integrated use allowed prediction of 79% of all the relapses with 93% specificity. 21102428 2011