|
IGHV3-69-1
|
0.080 |
Biomarker
|
disease |
BEFREE |
Finally, the disease-specific survival and the progression-free survival were significantly different between cases with mutated and unmutated IGHV genes, pointing out mutational status as a possible new biomarker in NMZL.
|
31802229 |
2019 |
|
IGHV3-69-1
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Our findings show, for the first time, a significant association between biased usage of autoreactive IGHV and somatic mutation of NF-κB regulators in MALT lymphoma, arguing for their cooperation in sustaining chronic B-cell receptor signalling and driving oncogenesis in lymphoma development.
|
28682481 |
2017 |
|
IGHV3-69-1
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
MALT lymphomas were usually associated with a mutated IGHV gene, but with the absence of selection pressure.
|
22944768 |
2013 |
|
IGHV3-69-1
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The observed patterns of V(H) usage and mutations suggested that specific antigens may play a pathologically relevant role in the genesis or progression of thymic MALT lymphoma.
|
16353132 |
2006 |
|
IGHV3-69-1
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Many diffuse large B-cell lymphomas (DLBCLs) of the stomach are believed to represent high-grade transformation of low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type, which is of memory B-cell origin, displaying evidence for positive antigen selection and a low level of ongoing somatic mutation of the rearranged immunoglobulin heavy-chain variable region (V(H)) genes.
|
14567725 |
2003 |
|
IGHV3-69-1
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
To clarify the cellular origin of extranodal marginal-zone B-cell lymphoma (EZML) of the mucosa-associated lymphoid tissue (MALT) type in ocular adnexa, the somatic mutation was analyzed in the immunoglobulin heavy-chain variable region (VH) gene.
|
11581182 |
2001 |
|
IGHV3-69-1
|
0.080 |
Biomarker
|
disease |
BEFREE |
Clonalities were detected by means of polymerase chain reaction (PCR), and immunoglobulin heavy-chain variable region (VH) genes were sequenced in 10 cases of mucosa-associated lymphoid tissue (MALT) lymphoma.
|
11454995 |
2001 |
|
IGHV3-69-1
|
0.080 |
Biomarker
|
disease |
BEFREE |
Based on the CDR3 sequence amplified from each MALT lymphoma, individual tumor-specific primers were synthesized and used directly in the polymerase chain reaction (PCR) to analyze the sequences of their Ig heavy-chain variable region.
|
7579460 |
1995 |