Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE These data indicate the protective role of CD39 in LPS‑induced renal tubular epithelial cell damage through inhibiting NLRP3 inflammasome activation and that CD39 might be a potential therapeutic target in sepsis‑induced AKI. 31545401 2019
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE The potential for targeting the NLRP3 inflammasome <i>in vivo</i> using RORγ inverse agonists was examined in two models: LPS-induced sepsis and fulminant hepatitis. 30455347 2019
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE We sought to determine the role of the nucleotide-binding domain, leucine-rich repeat-containing receptor, pyrin domain-containing-3 (NLRP3) inflammasome in polymicrobial sepsis and regulation of LM biosynthesis. 28245134 2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. 25574840 2015
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE The NLR family pyrin domain-containing 3 (NLRP3) inflammasome is a multimeric protein complex that mediates maturation of the cytokines IL-1β and IL-18 as well as release of the proinflammatory protein high-mobility group box 1 (HMGB1) and contributes to several inflammatory diseases, including sepsis, gout, and type 2 diabetes. 30971430 2019
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE TXNIP/NLRP3 serves an important role in the development of sepsis‑induced myocardial damage. 31173172 2019
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE Recombinant CC16 inhibits NLRP3/caspase-1-induced pyroptosis through p38 MAPK and ERK signaling pathways in the brain of a neonatal rat model with sepsis. 31775794 2019
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE Depletion of iNOS resulted in increased accumulation of dysfunctional mitochondria in response to LPS and ATP, which was responsible for the increased IL-1β production and caspase-1 activation. iNOS deficiency or pharmacological inhibition of NO production enhanced NLRP3-dependent cytokine production in vivo, thus increasing mortality from LPS-induced sepsis in mice, which was prevented by NLRP3 deficiency. 23318584 2013
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 AlteredExpression disease BEFREE This leads to a series of harmful events, some of which are connected to the cardiomyopathy of sepsis, resulting in defective action potentials in cardiomyocytes (CMs), activation of the NLRP3 inflammasome in CMs and the appearance of extracellular histones, likely arising from activated neutrophils which form neutrophil extracellular traps (NETs). 29914696 2018
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE NLRP3 inhibition may thus represent a novel therapeutic target that may protect the brain from toxic peripheral inflammation during systemic infection. 31359456 2019
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE α-Mangostin suppresses NLRP3 inflammasome activation via promoting autophagy in LPS-stimulated murine macrophages and protects against CLP-induced sepsis in mice. 30927050 2019
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE In this review, we elucidate evidences to understand the connection between sepsis development and the NLRP3 inflammasome, the most widely investigated member of this class of receptor. 31741197 2020
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE As NLRP3-dependent release of IL-1β has a critical role in sepsis, the <i>in vivo</i> activity of scutellarin was assayed in a mouse model of bacterial sepsis, which was established by intraperitoneally injection of a lethal dose of viable <i>Escherichia coli</i>. 29375379 2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE Furthermore, most sepsis-related deaths are among patients whose NLRP3 activation is profoundly altered. 31221993 2019
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE The purpose of this study was to assess the role played by TLR4 and by the NLRP3 inflammasome in the cardiac dysfunction that occurs after high-grade polymicrobial sepsis. 29176403 2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE Taken together, our work highlighted PRDX1 as a negative regulator of NLRP3 inflammasome activation and suggested AI-44 as a promising candidate compound for the treatment of sepsis or other NLRP3 inflammasome-driven diseases. 30185517 2018
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 AlteredExpression disease BEFREE Glucose-Insulin-Potassium Alleviates Intestinal Mucosal Barrier Injuries Involving Decreased Expression of Uncoupling Protein 2 and NLR Family-Pyrin Domain-Containing 3 Inflammasome in Polymicrobial Sepsis. 28428961 2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE It is known that Bruton's tyrosine kinase (BTK) plays a role in toll-like receptor signaling and NLRP3 inflammasome activation, two key components in the pathophysiology of sepsis and sepsis-associated cardiac dysfunction. 31552054 2019
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE The purpose of this study was to assess the role played by toll-like receptor 4 and by the NLRP3 inflammasome in the cardiac dysfunction that occurs after high-grade polymicrobial sepsis. 30216298 2018
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE The aim of this study was to assess the effects/mechanisms of CO-releasing molecule-3 (CORM-3)-dependent modulation of the NLRP3 inflammasome in cardiac fibroblasts (CF) and its effect on myocardial function in sepsis. 28168403 2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE The aim of the present study is to evaluate whether sepsis activates NLRP3 inflammasome/caspase-1/IL-1β pathway in cardiac fibroblasts (CFs) and whether this cytokine can subsequently impact the function of cardiomyocytes (cardiac fibroblast-myocyte cross-talk). 25216263 2014
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE In conclusion, to the best of our knowledge, the results of the present study demonstrated for the first time that overexpression of miRNA‑200a‑3p promoted inflammation in sepsis‑induced brain injury through reactive oxygen species‑induced NLRP3. 31485604 2019
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE Moreover, melatonin blunts the NF-κB/NLRP3 connection during sepsis. 28370493 2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE Thus, inhibition of Rab1a activity in macrophages resulting in the suppression of NLRP3 inflammasome activation may be a promising target for the treatment of patients with sepsis. 30455398 2019
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 AlteredExpression disease BEFREE Tim4 and NALP3 inflammasome expression in monocytes were downregulated in immunosuppressive patients with sepsis compared with healthy volunteers. 31676250 2019