Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 AlteredExpression disease BEFREE Glucose-Insulin-Potassium Alleviates Intestinal Mucosal Barrier Injuries Involving Decreased Expression of Uncoupling Protein 2 and NLR Family-Pyrin Domain-Containing 3 Inflammasome in Polymicrobial Sepsis. 28428961 2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE The aim of this study was to assess the effects/mechanisms of CO-releasing molecule-3 (CORM-3)-dependent modulation of the NLRP3 inflammasome in cardiac fibroblasts (CF) and its effect on myocardial function in sepsis. 28168403 2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE Moreover, melatonin blunts the NF-κB/NLRP3 connection during sepsis. 28370493 2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE These findings enhance our understanding of the critical role of NLRP3 in modulating autophagy and phagocytosis in neutrophils and suggest that therapies should be targeted to modulate autophagy and phagocytosis in neutrophils to control bacterial burden in tissues during CLP-induced polymicrobial sepsis. 28031338 2017
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. 25574840 2015
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE The aim of the present study is to evaluate whether sepsis activates NLRP3 inflammasome/caspase-1/IL-1β pathway in cardiac fibroblasts (CFs) and whether this cytokine can subsequently impact the function of cardiomyocytes (cardiac fibroblast-myocyte cross-talk). 25216263 2014
Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
0.100 Biomarker disease BEFREE Depletion of iNOS resulted in increased accumulation of dysfunctional mitochondria in response to LPS and ATP, which was responsible for the increased IL-1β production and caspase-1 activation. iNOS deficiency or pharmacological inhibition of NO production enhanced NLRP3-dependent cytokine production in vivo, thus increasing mortality from LPS-induced sepsis in mice, which was prevented by NLRP3 deficiency. 23318584 2013