Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
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0.100 | AlteredExpression | disease | BEFREE | Glucose-Insulin-Potassium Alleviates Intestinal Mucosal Barrier Injuries Involving Decreased Expression of Uncoupling Protein 2 and NLR Family-Pyrin Domain-Containing 3 Inflammasome in Polymicrobial Sepsis. | 28428961 | 2017 | ||||
|
0.100 | Biomarker | disease | BEFREE | The aim of this study was to assess the effects/mechanisms of CO-releasing molecule-3 (CORM-3)-dependent modulation of the NLRP3 inflammasome in cardiac fibroblasts (CF) and its effect on myocardial function in sepsis. | 28168403 | 2017 | ||||
|
0.100 | Biomarker | disease | BEFREE | Moreover, melatonin blunts the NF-κB/NLRP3 connection during sepsis. | 28370493 | 2017 | ||||
|
0.100 | Biomarker | disease | BEFREE | These findings enhance our understanding of the critical role of NLRP3 in modulating autophagy and phagocytosis in neutrophils and suggest that therapies should be targeted to modulate autophagy and phagocytosis in neutrophils to control bacterial burden in tissues during CLP-induced polymicrobial sepsis. | 28031338 | 2017 | ||||
|
0.100 | Biomarker | disease | BEFREE | UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. | 25574840 | 2015 | ||||
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0.100 | Biomarker | disease | BEFREE | The aim of the present study is to evaluate whether sepsis activates NLRP3 inflammasome/caspase-1/IL-1β pathway in cardiac fibroblasts (CFs) and whether this cytokine can subsequently impact the function of cardiomyocytes (cardiac fibroblast-myocyte cross-talk). | 25216263 | 2014 | ||||
|
0.100 | Biomarker | disease | BEFREE | Depletion of iNOS resulted in increased accumulation of dysfunctional mitochondria in response to LPS and ATP, which was responsible for the increased IL-1β production and caspase-1 activation. iNOS deficiency or pharmacological inhibition of NO production enhanced NLRP3-dependent cytokine production in vivo, thus increasing mortality from LPS-induced sepsis in mice, which was prevented by NLRP3 deficiency. | 23318584 | 2013 |