Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 AlteredExpression disease BEFREE The aim of the present study is to determine the association of melatonin hormone level on CRP, Total Antioxidant Status, Leukocyte, Procalcitonin, and Malondialdehyde, all acute phase reactants in the dark and light cycle of rats with sepsis model. 31806239 2020
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 AlteredExpression disease BEFREE Predictive value of C-reactive protein and NT-pro-BNP levels in sepsis patients older than 75 years: a prospective, observational study. 31214930 2020
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE PCT correlated with C-reactive protein as a biomarker for sepsis (P < 0.001), but not with other biomarkers. 31635838 2020
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE CRP analyzed on days 1 and 3, subsequently patients were identified in two groups: sepsis (<i>n</i> = 28) and no-sepsis (<i>n</i> = 67).<b>Results:</b> MPV was significantly higher on both day 1 (10.23 ± 0.92) fl and day 3 (10.77 ± 1.16) fL in the sepsis group compared with no-sepsis (8.11 ± 0.29) fl and (8.53 ± 0.42) fl, respectively. 29886794 2020
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 AlteredExpression disease BEFREE There were significantly higher serum levels of CRP among late onset versus early onset sepsis group with significantly higher serum levels of hsCRP and presepsin among early onset compared with the late onset sepsis group (p < 0.05 for all). 29895470 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE The area under the ROC curve (AUC) of HBP (cut-off ≥28.1 ng/mL) was 0.893 for sepsis which was higher than those of PCT (0.856) for a cut-off ≥2.05 ng/mL and of CRP (0.699) for a cut-off ≥151.9 mg/L. 31015272 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 GeneticVariation disease BEFREE A total of 1,110 patients diagnosed with sepsis were retrospectively analyzed to identify response patterns for risk stratification of routine parameters measured at the peak level of C-reactive protein. 31275752 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE (2) CRP and WBC were unable to predict sepsis (P > 0.05 for all), while PCT and NEU% could predict sepsis with areas under the curve (AUC) of 0.838 and 0.691, respectively (P < 0.05 for all). 30805753 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE It was not inferior to other laboratory values, including activated partial thromboplastin time (AUC: 0.729), C-reactive protein (AUC: 0.727), albumin (AUC: 0.834), prothrombin time (AUC: 0.816), and creatinine (AUC: 0.837) known to be associated with sepsis. 30985959 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE The C-reactive protein (CRP)/albumin ratio has been regarded as an outcome predictor in patients with cancer and sepsis. 31486619 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE The present study demonstrated that compared to CRP and PCT, PSEP is a superior biomarker for the postmortem differentiation of sepsis and that a concentration >1250 pg/mL is highly likely to indicate sepsis within 96 h of death. 30954003 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE Median CRP and PCT were highly and significantly increased during sepsis/SIRS and bacteremia (17.24 mg/dl ; 6.30 ng/ml; p < 0.0001 vs. prior values), graft rejection (14.73 mg/dl ; 3.20 ng/ml; p < 0.0001), and liver GvHD (6.88 mg/dl ; 2.29 ng/ml; p < 0.01). 31446489 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE Presepsin and resistin had similar performance as CRP and PCT for the diagnosis of infection (best cut-off of 1444 pg/ml and 20 ng/ml, respectively) and sepsis. 31221548 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE The aims of the present meta-analysis were to assess the overall diagnostic accuracy of presepsin in pediatric sepsis and compare it to those for C-reactive protein (CRP) and procalcitonin (PCT). 31470804 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE Several serum-based biomarkers such as C-reactive protein, lactate, presepsin, and cytokines, such as interleukin-1 (IL-1), and IL-6 have been evaluated as early indicators of sepsis but none have been proven sensitive and/or specific enough to make a definitive diagnosis. 31323346 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE The results of this study suggest that IL-6 is better than PCT and CRP in predicting the treatment success in predominantly non-surgical sepsis in the first 48-72 h. 30760225 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE Several lines of evidences suggest that PSP has a higher diagnostic performance for the identification of sepsis than procalcitonin and C-reactive protein, and a strong prognostic value to predict unfavorable outcome at admission to intensive care unit. 30672312 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 GeneticVariation disease BEFREE Death was the primary outcome in only one study and a survival benefit was not observed in the subset specified as sepsis (10 RCTs; RR, 0.94; 95% CI, 0.85-1.03; I<sup>2</sup> = 0%), those without industry sponsorship (nine RCTs; RR, 0.98; 95% CI, 0.87-1.10; I<sup>2</sup> = 0%), high PCT-guided algorithm adherence (five RCTs; RR, 0.93; 95% CI, 0.71-1.22; I<sup>2</sup> = 0%), and PCT-guided algorithms without C-reactive protein (eight RCTs; RR, 0.96; 95% CI, 0.87-1.06; I<sup>2</sup> = 0%). 30772386 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE The prognostic value of bioscore and SOFA was similar for predicting 90-day mortality.<b>Conclusions:</b> The new bioscore formed by combination of CRP, PCT and SOFA score may be useful in early diagnosis of sepsis. 31687850 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 AlteredExpression disease BEFREE Mechanical ventilation, white blood cell (WBC) counts, C-reactive protein (CRP) and lactate levels, maximum 24-h APACHE-II scores, and AGP concentrations were significantly higher upon admission in patients with sepsis who died. 31309103 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE Toward Early Diagnosis of Late-Onset Sepsis in Preterm Neonates: Dual Magnetoimmunosensor for Simultaneous Procalcitonin and C-Reactive Protein Determination in Diagnosed Clinical Samples. 31305070 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE Significant differences in NLCR values were observed between sepsis and non-sepsis patients (15.3 [10.8-38.2] (median [interquartile range] vs. 9.3 [6.2-14.5]; P<0.001), as well as for CRP level, PCT level and lymphocyte count. 30811475 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 Biomarker disease BEFREE The application of PCT to predict local infection in patients with T2DM was identified to be inferior to CRP, but its ability to predict sepsis was concluded to be the best when compared with CRP, white blood cell count and neutrophil percent. 31258707 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 GeneticVariation disease BEFREE We performed a systematic review and meta-analysis to evaluate the diagnostic accuracy of neutrophil CD64, comparing it with C-reactive protein (CRP) and procalcitonin (PCT) for the diagnosis of infection in adult patients with septic syndrome, based on sepsis-2 criteria. 30623257 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.300 AlteredExpression disease BEFREE Comparison of markers of sepsis revealed C-reactive protein, interleukin-6 level to be significantly higher and pH, pCO<sub>2</sub>, HCO<sub>3,</sub> and base excess values to be significantly lower in newborns with sepsis compared healthy controls (p<0.01). 30858952 2019