Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 AlteredExpression disease BEFREE The expression levels of HMGB-1 and TF of the rats with sepsis gradually increased with time, and the level of HMGB-1 was positively correlated with the level of TF. 30840287 2019
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 Biomarker disease BEFREE This study sought to determine the role of tissue factor associated with adipose-derived MSCs (ASCs) in their procoagulant and antibacterial effects during pneumonia-derived sepsis. 31547876 2019
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 Biomarker disease BEFREE It was not inferior to other laboratory values, including activated partial thromboplastin time (AUC: 0.729), C-reactive protein (AUC: 0.727), albumin (AUC: 0.834), prothrombin time (AUC: 0.816), and creatinine (AUC: 0.837) known to be associated with sepsis. 30985959 2019
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 AlteredExpression disease BEFREE Bub1 insufficiency attenuates TF expression and reduces TM suppression by blocking Akt and JNK phosphorylation, respectively, thus leading to the prevention of ARF and death caused by sepsis. 29608549 2019
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 Biomarker disease BEFREE Circulating tissue factor (TF), the main initiator of coagulation, has a central role in the development of coagulation disturbances during sepsis. 28024455 2017
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 Biomarker disease BEFREE Enhanced thrombin generation without activators and the PS-inducing capacity of septic plasma are signs of hemostatic activation during fulminant sepsis while the decreased amount of generated thrombin upon tissue factor and phospholipid induced activation demonstrates attenuated thrombin forming ability. 28802974 2017
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 AlteredExpression disease BEFREE In sepsis, binding of factor VII (FVII:C) and activated factor VII (FVIIa) with tissue factor is the key step of coagulation resulting in disseminated intravascular coagulation (DIC). 28492702 2017
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 Biomarker disease BEFREE This study aimed to evaluate TF/CD13MPs and assess their usefulness as a biomarker of pathogenesis in early SIRS following trauma and sepsis. 27753793 2017
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 Biomarker disease BEFREE Furthermore, the identification of platelet TF and TLR4 as regulators of the effect of E. coli O111 might represent a novel therapeutic target to reduce the devastating consequences of the hemostatic disorder during sepsis. 28957360 2017
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 Therapeutic disease RGD Sodium tanshinone II A sulfonate ameliorates microcirculatory disturbance of small intestine by attenuating the production of reactie oxygen species in rats with sepsis. 26311287 2016
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 Biomarker disease BEFREE Tissue factor (TF) is a key initiating component in intravascular coagulation in sepsis, and long pentraxin 3 (PTX3) enhances the lipopolysaccharide (LPS)-induced transcription of TF. 26241501 2015
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 Biomarker disease BEFREE Seventeen SNPs in TF and TFPI were genotyped in samples of sepsis (n =577) and severe sepsis patients (n =476), and tested for association in this case-control collection. 25407675 2014
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 AlteredExpression disease BEFREE Because the nuclear factor-κB (NF-κB) coupled pathway is believed to amplify inflammation prevailing in sepsis, the authors tested the hypotheses that the insertion-deletion polymorphism (-94ins/delATTG) (1) alters nuclear translocation of nuclear factor-κB and activator protein-1 (NF-κB1) in monocytes after lipopolysaccharide stimulation; (2) affects lipopolysaccharide-induced NF-κB1 messenger RNA expression, tumor necrosis factor α concentrations, and tissue factor activity; and (3) may be associated with increased 30-day mortality in patients with sepsis. 23249930 2013
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 Biomarker disease BEFREE Availability of hemophilic mice (by specific knock-out of FVIII or FIX genes) and novel TF transgenic mice has allowed us in recent years to investigate the importance of TF-FVIIa-induced coagulation from wound healing to sepsis. 20153022 2010
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 Biomarker disease BEFREE Tissue factor (TF) plays a central role during disseminated intravascular coagulation (DIC) in sepsis. 16634740 2006
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 AlteredExpression disease BEFREE An aberrant expression of TF within the vasculature occurs in a variety of diseases, including atherosclerosis, cancer, and sepsis. 16479457 2006
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 AlteredExpression disease BEFREE In addition, aberrant TF expression within the vasculature initiates life-threatening thrombosis in various diseases, such as sepsis, atherosclerosis, and cancer. 15117736 2004
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 Biomarker disease BEFREE However, the emerging role of TF in the pathogenesis of diseases such as sepsis, atherosclerosis, certain cancers and diseases characterized by pathological fibrin deposition such as disseminated intravascular coagulation and thrombosis, has directed attention to the development of novel inhibitors of tissue factor for use as antithrombotic drugs. 15389118 2004
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 AlteredExpression disease BEFREE Thus, NO could play an antithrombotic role in sepsis by down-regulating the endothelial overexpression and production of TF. 12529760 2002
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 Biomarker disease BEFREE In contrast to its beneficial role in hemostasis, TF initiates life-threatening intravascular thrombosis in sepsis, atherosclerosis and cancer. 11171553 2001
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 AlteredExpression disease BEFREE These results suggest that FXa is an important factor for TF expression in sepsis. 11685190 2001
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 Biomarker disease LHGDN The pleiotropic effects of tissue factor: a possible role for factor VIIa-induced intracellular signalling? 11776298 2001
Entrez Id: 2152
Gene Symbol: F3
F3
0.300 AlteredExpression disease BEFREE Tissue factor (TF) is the principal cellular initiator of coagulation and its deregulated expression has been related to thrombogenesis in sepsis, cancer, and inflammation. 9186598 1997