Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4049
Gene Symbol: LTA
LTA
0.380 Biomarker disease BEFREE The association of theses SNPs with the following parameters was evaluated: (1) the presence of sepsis; (2) severity and clinical outcomes; (3) APACHE II and SOFA scores; and (4) procalcitonin, C-reactive protein, tumor necrosis factor, lymphotoxin alpha, interleukin 1 beta and interleukin 10 plasma concentrations. 27592234 2016
Entrez Id: 4049
Gene Symbol: LTA
LTA
0.380 Biomarker disease BEFREE Genotypes of TNF-β and the production of TNF-α were related to the occurrence of sepsis. 24796628 2014
Entrez Id: 4049
Gene Symbol: LTA
LTA
0.380 GeneticVariation disease BEFREE This study aimed to evaluate the influence of SNPs LTA +252A>G, TNF-863C>A and TNF-308G>A on susceptibility to sepsis, acute respiratory distress syndrome (ARDS), septic shock and sepsis mortality. 22507624 2012
Entrez Id: 4049
Gene Symbol: LTA
LTA
0.380 Biomarker disease CTD_human Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility. 22977509 2011
Entrez Id: 4049
Gene Symbol: LTA
LTA
0.380 GeneticVariation disease BEFREE Association between lymphotoxin-α intron +252 polymorphism and sepsis: a meta-analysis. 21366408 2011
Entrez Id: 4049
Gene Symbol: LTA
LTA
0.380 Biomarker disease BEFREE Thus, we investigated the possible association between 12 polymorphisms located in the interleukin-6 (IL6), IL10, TLR-2, Toll-like receptor-4 (TLR-4), tumor necrosis factor-α and tumor necrosis factor-β (lymphotoxin α--LTA) genes and sepsis. 20835611 2010
Entrez Id: 4049
Gene Symbol: LTA
LTA
0.380 GeneticVariation disease BEFREE To evaluate the importance of the LT-alpha (+250 G/A) polymorphism for the clinical outcome of patients developing postsurgical sepsis, 85 patients were consecutively included into this study. 15187748 2004
Entrez Id: 4049
Gene Symbol: LTA
LTA
0.380 GeneticVariation disease BEFREE These data indicate an association between TNFbeta polymorphism and postoperative complications and they suggest the B2/B2 genotype as a high risk factor for the development of sepsis after elective operative trauma. 12558135 2003
Entrez Id: 4049
Gene Symbol: LTA
LTA
0.380 GeneticVariation disease BEFREE In contrast to the TNF-beta NcoI polymorphism, which has been associated with patients' nonsurvival, the allele IL-1raA2 of the polymorphism within the intron 2 of IL-1ra may contribute to susceptibility to sepsis. 10446828 1999