In this study, we found that <i>Il1f6</i><sup>-/-</sup> mice developed milder psoriasiform dermatitis upon treatment with imiquimod, a ligand for TLR ligand 7 (TLR7) and TLR8, whereas <i>Il1f6</i><sup>-/-</sup> mice showed similar susceptibility to dextran sodium sulfate-induced colitis to wild-type mice.