Higher PD-L1 expression was associated with higher PD-1 expression (<i>P</i><0.001), higher CD4 (<i>P</i><0.001) and CD8 (<i>P</i><0.001) density and DNA mismatch repair deficiency (<i>P</i>=0.01).
A comprehensive miRNA screening using The Cancer Genome Atlas (TCGA) dataset (<i>n</i> = 260) combined with eight different miRNA target prediction programs resulted in the identification of a tumor suppressive miRNA, miR-148a-3p, as a potential negative regulator of PD-L1 expression, particularly in dMMR/MSI-H colorectal cancer.
Mismatch repair deficiency is associated with MSI phenotype, increased tumor-infiltrating lymphocytes and PD-L1 expression in immune cells in ovarian cancer.