| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | DNA mismatch repair deficiency but not ARID1A loss is associated with prognosis in small intestinal adenocarcinoma. | 30381262 | 2019 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | MMR deficiency was identified in 5% (17/316) but was detected more frequently in ARID1A-loss adenocarcinomas (13/41, 32%) than in ARID1A-retained adenocarcinomas (4/275, 1%; P < .001). | 31655170 | 2019 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Pathogenic BRCA1 and ARID1A mutations were inversely associated with each other (p<0.001), were not associated with MMR-deficiency or CD8+ density, but both independently predicted for unfavorable DFS (HR=1.98, 95%CI 1.12-3.48, p=0.018 and HR=1.99, 95%CI 1.11-3.54, p=0.020, respectively). | 30479693 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | In conclusion, loss of ARID1A is more common in advanced GC and is related to EBV positivity and MMR deficiency. | 26067140 | 2017 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | The tumors with abnormal ARID1A expression more frequently indicated MMR deficiency (47.4% vs 20.2%, P<0.001). | 25717252 | 2015 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We conclude that loss of ARID1A expression occurs in a small but significant proportion of CRCs where it is strongly correlated with mismatch repair deficiency and other clinical and pathological features associated with somatic hypermethylation. | 24925223 | 2014 | ||||
|
0.080 | Biomarker | disease | BEFREE | In conclusion, BAF250a loss is more common in high-grade endometrioid carcinomas than in other high-grade endometrial cancers and is associated with mismatch repair deficiency and normal p53 expression. | 23887303 | 2014 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The association with dMMR in HGEC with ARID1A/PTEN alterations, TP53 wild type expression pattern and unfavorable outcome suggests that different oncogenetic pathways within HGEC are present. | 23938375 | 2013 |