Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6862
Gene Symbol: TBXT
TBXT 		0.300 Biomarker disease CTD_human
Entrez Id: 6347
Gene Symbol: CCL2
CCL2 		0.300 Biomarker disease CTD_human
Entrez Id: 80199
Gene Symbol: FUZ
FUZ 		0.300 Biomarker disease CTD_human
Entrez Id: 280636
Gene Symbol: SELENOH
SELENOH 		0.020 Biomarker disease BEFREE Exencephaly frequency is reduced in SELH/Bc by an alternative commercial ration. 19117321 2009
Entrez Id: 4522
Gene Symbol: MTHFD1
MTHFD1 		0.300 Biomarker disease CTD_human A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group. 12384833 2002
Entrez Id: 84678
Gene Symbol: KDM2B
KDM2B 		0.010 Biomarker disease BEFREE About half of Fbxl10-deficient mice exhibit failure of neural tube closure, resulting in exencephaly and die shortly after birth. 21220025 2011
Entrez Id: 10370
Gene Symbol: CITED2
CITED2 		0.010 Biomarker disease BEFREE Among responsive mutants, folic acid supplementation reduces exencephaly and/or spina bifida aperta frequency in the Sp(2H), Sp, Cd, Cited2, Cart1, and Gcn5 mutants.Prevention ranges from 35 to 85%. 19117321 2009
Entrez Id: 9727
Gene Symbol: RAB11FIP3
RAB11FIP3 		0.010 Biomarker disease BEFREE Among responsive mutants, folic acid supplementation reduces exencephaly and/or spina bifida aperta frequency in the Sp(2H), Sp, Cd, Cited2, Cart1, and Gcn5 mutants.Prevention ranges from 35 to 85%. 19117321 2009
Entrez Id: 8092
Gene Symbol: ALX1
ALX1 		0.010 Biomarker disease BEFREE Among responsive mutants, folic acid supplementation reduces exencephaly and/or spina bifida aperta frequency in the Sp(2H), Sp, Cd, Cited2, Cart1, and Gcn5 mutants.Prevention ranges from 35 to 85%. 19117321 2009
Entrez Id: 9618
Gene Symbol: TRAF4
TRAF4 		0.010 Biomarker disease BEFREE Among responsive mutants, folic acid supplementation reduces exencephaly and/or spina bifida aperta frequency in the Sp(2H), Sp, Cd, Cited2, Cart1, and Gcn5 mutants.Prevention ranges from 35 to 85%. 19117321 2009
Entrez Id: 2648
Gene Symbol: KAT2A
KAT2A 		0.010 GeneticVariation disease BEFREE Among responsive mutants, folic acid supplementation reduces exencephaly and/or spina bifida aperta frequency in the Sp(2H), Sp, Cd, Cited2, Cart1, and Gcn5 mutants.Prevention ranges from 35 to 85%. 19117321 2009
Entrez Id: 3630
Gene Symbol: INS
INS 		0.300 Therapeutic disease CTD_human Arsenate-induced maternal glucose intolerance and neural tube defects in a mouse model. 19446573 2009
Entrez Id: 2350
Gene Symbol: FOLR2
FOLR2 		0.300 Biomarker disease CTD_human Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice. 11749123 2001
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		0.300 Biomarker disease CTD_human Association of the maternal MTHFR C677T polymorphism with susceptibility to neural tube defects in offsprings: evidence from 25 case-control studies. 23056169 2012
Entrez Id: 1544
Gene Symbol: CYP1A2
CYP1A2 		0.300 Biomarker disease CTD_human Caffeine, selected metabolic gene variants, and risk for neural tube defects. 20641098 2010
Entrez Id: 10
Gene Symbol: NAT2
NAT2 		0.300 Biomarker disease CTD_human Caffeine, selected metabolic gene variants, and risk for neural tube defects. 20641098 2010
Entrez Id: 4651
Gene Symbol: MYO10
MYO10 		0.010 GeneticVariation disease BEFREE Complete knockout of Myo10 is semi-lethal, with over half of homozygous KO embryos exhibiting exencephaly, a severe defect in neural tube closure. 29229982 2017
Entrez Id: 4522
Gene Symbol: MTHFD1
MTHFD1 		0.300 Biomarker disease CTD_human Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population. 16552426 2006
Entrez Id: 57216
Gene Symbol: VANGL2
VANGL2 		0.300 Biomarker disease CTD_human Cranial effects of retinoic acid in the loop-tail (Lp) mutant mouse. 2373757 1990
Entrez Id: 5077
Gene Symbol: PAX3
PAX3 		0.310 GeneticVariation disease BEFREE Crosses of white-spotted mice showed that homozygosity for the mutation caused tail and limb abnormalities and embryonic lethality as a result of exencephaly; these phenotypes were analogous to those found in other Pax3 mutants. 28381738 2017
Entrez Id: 57822
Gene Symbol: GRHL3
GRHL3 		0.310 Biomarker disease CTD_human Differential response of heterozygous curly-tail mouse embryos to vitamin A teratogenesis depending on maternal genotype. 6635991 1983
Entrez Id: 2737
Gene Symbol: GLI3
GLI3 		0.300 Biomarker disease CTD_human Exencephaly induction by valproic acid in the genetic polydactyly/arhinencephaly mouse, Pdn/Pdn. 16359493 2005
Entrez Id: 5652
Gene Symbol: PRSS8
PRSS8 		0.300 Therapeutic disease CTD_human Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea. 24722141 2014
Entrez Id: 10653
Gene Symbol: SPINT2
SPINT2 		0.300 Biomarker disease CTD_human Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea. 24722141 2014
Entrez Id: 5697
Gene Symbol: PYY
PYY 		0.300 Biomarker disease CTD_human Gastrointestinal hormones (anorexigenic peptide YY and orexigenic ghrelin) influence neural tube development. 17400914 2007