Gene: TRPC6 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7225
Gene Symbol: TRPC6
TRPC6 		0.400 Biomarker group BEFREE These data suggest that knockout of TRPC6 in Akita mice promotes insulin resistance and exacerbates glomerular disease independent of hyperglycemia. 30665571 2019
Entrez Id: 7225
Gene Symbol: TRPC6
TRPC6 		0.400 AlteredExpression group BEFREE Several studies have identified gain-of-function mutations of <i>TRPC6</i> and report induced expression and enhanced channel activity of TRPC6 in association with glomerular diseases. 28877958 2018
Entrez Id: 7225
Gene Symbol: TRPC6
TRPC6 		0.400 Biomarker group BEFREE Increased calcium ion entry through the TRPC6 channel has been associated with the pathogenesis of heart and glomerular diseases, but its role in renal interstitial fibrosis is unknown. 27979597 2017
Entrez Id: 7225
Gene Symbol: TRPC6
TRPC6 		0.400 AlteredExpression group BEFREE Transient receptor potential channel C6 (TRPC6) gain-of-function mutations and increased TRPC6 expression in podocytes induce glomerular injury and proteinuria. 27895156 2017
Entrez Id: 7225
Gene Symbol: TRPC6
TRPC6 		0.400 Biomarker group BEFREE Therefore, we provide evidence demonstrating the critical role of Ang II/TRPC6 axis in the control of glomeruli function, which is likely important for the development of glomerular diseases. 28331185 2017
Entrez Id: 7225
Gene Symbol: TRPC6
TRPC6 		0.400 Biomarker group BEFREE GPCRs coupled to Gq signaling activate TRPC6, suggesting that Gq-dependent TRPC6 activation underlies glomerular diseases. 25844902 2015
Entrez Id: 7225
Gene Symbol: TRPC6
TRPC6 		0.400 Biomarker group BEFREE Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease. 24194522 2013
Entrez Id: 7225
Gene Symbol: TRPC6
TRPC6 		0.400 AlteredExpression group BEFREE Vitamin D down-regulates TRPC6 expression in podocyte injury and proteinuric glomerular disease. 23385000 2013
Entrez Id: 7225
Gene Symbol: TRPC6
TRPC6 		0.400 AlteredExpression group BEFREE Angiotensin II (AngII) is a key contributor to glomerular disease and may regulate TRPC6 expression in nonrenal cells. 21839714 2011
Entrez Id: 7225
Gene Symbol: TRPC6
TRPC6 		0.400 AlteredExpression group BEFREE In addition, acquired glomerular diseases are associated with increased expression levels of TRPC6. 20877463 2010
Entrez Id: 7225
Gene Symbol: TRPC6
TRPC6 		0.400 Biomarker group BEFREE It seems that TRPC6 is a gene with a very variable penetrance that may contribute to glomerular diseases in a multi-hit setting. 19458060 2009
Entrez Id: 7225
Gene Symbol: TRPC6
TRPC6 		0.400 Biomarker group GENOMICS_ENGLAND