While these results suggest that LRRK2R1398H or N551K do not appear to modulate the risk of ET, it remains possible that a protective trend for both variants may be present in ET and a much larger sample size is required to identify this.
The data suggest that LRRK1 variant (rs2924835) and LRRK2 variants (rs34594498, rs34410987, and rs33949390) are not associated with ET in this Han Chinese population.
To evaluate the frequency of the LRRK2P755L variant in North American Caucasian patients with PD, we screened 426 PD patients and 37 additional patients with the combination of PD and essential tremor (ET) from our Parkinson Disease Center and Movement Clinic at Baylor College of Medicine.
Since phenotypes of PD overlap with essential tremor (ET), we investigated LRRK2G2019S, I2012T, and I2020T mutations in a cohort of 272 patients with ET.