|
PPARGC1A
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
EPA rescued the weight gain and glucose intolerance in UCP1 KO mice at thermoneutrality, independent of UCP1; these effects may be mediated in part via increased oxygen consumption and BAT PGC1α.
|
30657255 |
2019 |
|
PPARGC1A
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
The present findings showed that administration of baicalin decreased food intake, body weight, HOMA-IR and p-p38 MAPK and pERK levels, but enhanced pAKT and PGC-1α contents, as well as GLUT4 mRNA, PGC-1α mRNA expression in adipocytes, and reversed high fat diet-induced glucose intolerance, hyperglycemia and insulin resistance in diet-induced obese mice.
|
29526684 |
2018 |
|
PPARGC1A
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, our results indicated that whole-body glucose metabolism and glucose intolerance in OVX rats was degressive, suggesting there was a novel link between osteoporosis and whole body glucose homeostasis, which are controlled by the P38MAPK/PGC-1α/GLUT4 signaling pathway.
|
30292771 |
2018 |
|
PPARGC1A
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Efforts to promote mitochondrial biogenesis through peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) to mitigate glucose intolerance have been controversial.
|
28639297 |
2017 |
|
PPARGC1A
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of PGC-1α in β cells during fetal life in mice is sufficient to induce β-cell dysfunction in adults, leading to glucose intolerance.
|
25753246 |
2015 |
|
PPARGC1A
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
We measured the metabolic parameters and the expression of PPARgamma and PGC-1alpha mRNA using quantitative real-time PCR in omental and subcutaneous (SC) adipose tissues in an observational study of 153 individuals as well as in SC fat and skeletal muscle in an interventional study of 60 subjects (20 each with normal glucose tolerance, impaired glucose tolerance, and T2D) before and after intensive physical training for 4 weeks.
|
19966034 |
2010 |
|
PPARGC1A
|
0.090 |
GeneticVariation
|
phenotype |
BEFREE |
To address this question, we generated skeletal muscle-specific PGC-1alpha knockout mice (MKOs), which developed significantly impaired glucose tolerance but showed normal peripheral insulin sensitivity.
|
17932564 |
2007 |
|
PPARGC1A
|
0.090 |
GeneticVariation
|
phenotype |
LHGDN |
Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP-NIDDM trial.
|
16804087 |
2006 |
|
PPARGC1A
|
0.090 |
GeneticVariation
|
phenotype |
BEFREE |
Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial.
|
15592662 |
2004 |