|
HLA-DRB1
|
0.070 |
Biomarker
|
disease |
BEFREE |
Among the genetic factors for isolated AAD and autoimmune polyendocrine syndrome type 2, a key role is played by HLA class II genes: HLA-DRB1*0301-DQA1*0501-DQB1*0201 and DRB1*04-DQA1*0301-DQB1*0302 are positively, and DRB1*0403 is negatively, associated with genetic risk for AAD.
|
27211051 |
2016 |
|
HLA-DRB1
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Heterozygotes of the single-nucleotide polymorphisms (SNPs) rs397515394, rs6467, rs6474, rs76565726 and rs6473 were detected significantly more frequently in AAD patients compared with HC (P<0.005), but all SNPs were in a linkage disequilibrium (LD) with high-risk HLA-DRB1 haplotypes. rs6472C protected against AAD (odds ratio=0.15, 95% CI (0.08-0.30), P=3.8×10(-10)).
|
25249698 |
2014 |
|
HLA-DRB1
|
0.070 |
Biomarker
|
disease |
BEFREE |
After conditioning on DRB1, association with AAD was still present for HLA-B and MICA, suggesting the presence of additional risk factors.
|
21816777 |
2011 |
|
HLA-DRB1
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Eighty-six 21-hydroxylase autoantibody-positive, nonautoimmune polyendocrine syndrome type 1, Caucasian individuals collected from 1992 to 2009 with clinical AD from 68 families (12 multiplex and 56 simplex) were genotyped for HLA-DRB1, HLA-DQB1, MICA, HLA-B, and HLA-A as well as high density MHC single-nucleotide polymorphism (SNP) analysis for 34.
|
20631027 |
2010 |
|
HLA-DRB1
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Multivariate logistic regression analysis showed that CTLA4+49 allele G was positively associated with AAD (P<0.0001, odds ratio (OR)=2.43, 95% confidence interval=1.54-3.86) also after correction for DRB1*03-DQA1*0501-DQB1*0201, DRB1*04-DQA1*0301-DQB1*0302, and sex.
|
19884265 |
2010 |
|
HLA-DRB1
|
0.070 |
Biomarker
|
disease |
BEFREE |
Multivariate logistic regression analysis showed that MHC2TA AG+GG continued to be positively associated with genetic risk for AAD (P = 0.028, odds ratio = 1.72, 95% confidence interval = 1.06-2.78), after correction for DRB1*03-DQA1*0501-DQB1*0201, DRB1*04 (not 0403)-DQA1*0301-DQB1*0302 and DRB1*0403.
|
16849401 |
2006 |
|
HLA-DRB1
|
0.070 |
Biomarker
|
disease |
BEFREE |
Multivariate logistic regression analysis revealed that DQ-LTR13 is not independently associated with type 1 diabetes and AAD after correction for DQB1*0302 and DRB1*0403.
|
15734871 |
2005 |