Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
0.040 GeneticVariation disease BEFREE The association between AA and GSTT1 deletion suggests a role of glutathione-conjugation in AA, possibly through protecting the hematopoietic compartment from endogenous metabolites or environmental exposures. 23798465 2013
Entrez Id: 27306
Gene Symbol: HPGDS
HPGDS
0.040 GeneticVariation disease BEFREE Several case-control studies linked homozygous deletion of the glutathione S-transferase theta (GSTT1) gene to AA; however, the role of GSTT1 deletion remains controversial as other studies failed to confirm the association. 23798465 2013
Entrez Id: 27306
Gene Symbol: HPGDS
HPGDS
0.040 GeneticVariation disease BEFREE Genetic polymorphism of the detoxifying enzymes, the glutathione-S-transferase (GST) and microsomal epoxide hydrolase (mEh), with alteration in their activities could explain the genetic interindividual risks for AA. 21228718 2011
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
0.040 GeneticVariation disease BEFREE We analyzed the impact of the polymorphisms in CYP4501A1 and GSTM1 and GSTT1 genes on the susceptibility and disease severity in 200 patients with AA and compared the frequency with the normal population. 16227674 2005
Entrez Id: 27306
Gene Symbol: HPGDS
HPGDS
0.040 GeneticVariation disease BEFREE The aim of the study was to characterize the genetic polymorphism of biotransforming phase I (p450-cyp2E1) and phase II [microsomal epoxide hydrolase (mEh), glutathione S-transferase (GST)] enzymes in pediatric patients with acquired aplastic anemia. 14681495 2004
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
0.040 GeneticVariation disease BEFREE The GSTT1 null genotype (absence of both alleles) was associated with a significantly increased risk for acquired aplastic anemia (odds ratio, 2.8; 95% confidence interval, 0.15-5.7). 14681495 2004
Entrez Id: 2952
Gene Symbol: GSTT1
GSTT1
0.040 GeneticVariation disease BEFREE Increased frequencies of glutathione S-transferase (GSTM1 and GSTT1) gene deletions in Korean patients with acquired aplastic anemia. 11719393 2001
Entrez Id: 27306
Gene Symbol: HPGDS
HPGDS
0.040 GeneticVariation disease BEFREE Increased frequencies of glutathione S-transferase (GSTM1 and GSTT1) gene deletions in Korean patients with acquired aplastic anemia. 11719393 2001
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.030 Biomarker disease BEFREE G-CSF for patients with AA is not associated with a higher occurrence of secondary malignant neoplasm, mainly MDS/AML, or PNH. 30253387 2018
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.030 AlteredExpression disease BEFREE We have investigated the expression of RNA transcripts of hematopoiesis regulatory molecules, viz., macrophage inflammatory protein (MIP)-1<i>α</i>, tumor necrosis factor (TNF)-<i>α</i>, granulocyte colony-stimulating factor (G-CSF), stromal cell-derived factor (SDF)-1<i>α</i>, stem cell factor (SCF), and transforming growth factor (TGF)-<i>β</i> in lipopolysaccharide-induced bone marrow mesenchymal stem cells (BM-MSCs) and levels of their soluble forms in the culture supernatants of BM-MSCs and BM plasma of patients with acquired aplastic anemia (AA) (<i>n</i> = 29) and controls (<i>n</i> = 29). 30416525 2018
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.030 GeneticVariation disease BEFREE The markedly high prevalence of leukocytes lacking HLA-B4002 as a result of either 6pLOH or structural gene mutations, or both, suggests that antigen presentation by hematopoietic stem/progenitor cells to cytotoxic T cells via the HLA-B allele plays a critical role in the pathogenesis of AA. 28232583 2017
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.030 GeneticVariation disease BEFREE Novel deletion mutation of HLA-B*40:02 gene in acquired aplastic anemia. 28025876 2017
Entrez Id: 3669
Gene Symbol: ISG20
ISG20
0.030 Biomarker disease BEFREE Recently enhanced T-helper type 17 (Th17) immune responses and deficient CD4(+) CD25(hi) FoxP3(+) regulatory T cells (Tregs) have been reported in acquired aplastic anemia (AA). 25784172 2015
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.030 Biomarker disease BEFREE Recently enhanced T-helper type 17 (Th17) immune responses and deficient CD4(+) CD25(hi) FoxP3(+) regulatory T cells (Tregs) have been reported in acquired aplastic anemia (AA). 25784172 2015
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.030 Biomarker disease BEFREE CD4(+)CD25(+) regulatory T cells (Tregs) were believed to control development and progression of autoimmunity by suppressing autoreactive effector T cells, but little was known regarding the function of Tregs in AA. 22797698 2012
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
0.030 GeneticVariation disease BEFREE Correlations between HLA-A, HLA-B and HLA-DRB1 allele polymorphisms and childhood susceptibility to acquired aplastic anemia. 22572536 2012
Entrez Id: 3669
Gene Symbol: ISG20
ISG20
0.030 Biomarker disease BEFREE CD4(+)CD25(+) regulatory T cells (Tregs) were believed to control development and progression of autoimmunity by suppressing autoreactive effector T cells, but little was known regarding the function of Tregs in AA. 22797698 2012
Entrez Id: 3559
Gene Symbol: IL2RA
IL2RA
0.030 Biomarker disease BEFREE Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia. 17463169 2007
Entrez Id: 3669
Gene Symbol: ISG20
ISG20
0.030 Biomarker disease BEFREE Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia. 17463169 2007
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.030 Biomarker disease BEFREE We report on a female patient with acquired aplastic anemia whose bone marrow cells showed DNA rearrangement of the immunoglobulin-JH region that disappeared after 1 month with recovery of hematopoiesis through treatment with granulocyte colony-stimulating factor (G-CSF) and immunosuppressive drugs. 10641438 1999
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.020 Biomarker disease BEFREE Interleukin-2 (alias: IL-2, TCGF, Lymphokine), a type of interleukin, is also a potent signalling molecule in the signalling cascade of the immune-mediated activation of T Lymphocytes leading to the destruction of haematopoietic stem cell (HSC) which is the basis of acquired aplastic anaemia (AAA). 30139310 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.020 AlteredExpression disease BEFREE We have investigated the expression of RNA transcripts of hematopoiesis regulatory molecules, viz., macrophage inflammatory protein (MIP)-1<i>α</i>, tumor necrosis factor (TNF)-<i>α</i>, granulocyte colony-stimulating factor (G-CSF), stromal cell-derived factor (SDF)-1<i>α</i>, stem cell factor (SCF), and transforming growth factor (TGF)-<i>β</i> in lipopolysaccharide-induced bone marrow mesenchymal stem cells (BM-MSCs) and levels of their soluble forms in the culture supernatants of BM-MSCs and BM plasma of patients with acquired aplastic anemia (AA) (<i>n</i> = 29) and controls (<i>n</i> = 29). 30416525 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A
0.020 Biomarker disease BEFREE We investigated CXCR4 expressions on circulating T-cell subsets, plasma IL-17A concentrations, and their correlations with AA manifestations. 28831064 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.020 Biomarker disease BEFREE This initial analysis provides valuable clues for further study of TGF-β1 pathway genes in acquired AA. 27933374 2017
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.020 Biomarker disease BEFREE Interleukin-2 and Interleukin-8 Gene Polymorphisms and Acquired Aplastic Anemia Risk in a Chinese Population. 28268223 2017