Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7066
Gene Symbol: THPO
THPO 		0.100 AlteredExpression disease BEFREE Thrombopoietin level predicts response to treatment with eltrombopag and romiplostim in immune thrombocytopenia. 30187942 2018
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Phase 3 randomised study of avatrombopag, a novel thrombopoietin receptor agonist for the treatment of chronic immune thrombocytopenia. 30191972 2018
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Efficacy and safety of thrombopoietin receptor agonists in children with chronic immune thrombocytopenia: a meta-analysis. 29467954 2018
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE In absence of direct comparison, we conducted an indirect-comparison meta-analysis to evaluate the efficacy and safety of thrombopoietin-receptor agonists(TPO-RAs) in treatment of pediatric persistent or chronic immune thrombocytopenia(ITP). 29330464 2018
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Autoantibodies to thrombopoietin and the thrombopoietin receptor in patients with immune thrombocytopenia. 29532903 2018
Entrez Id: 7066
Gene Symbol: THPO
THPO 		0.100 Biomarker disease BEFREE Romiplostim, a thrombopoietin mimetic, is efficacious as a second-line treatment for immune thrombocytopenia in children and for TRT in adult cancer patients. 28150377 2017
Entrez Id: 7066
Gene Symbol: THPO
THPO 		0.100 Biomarker disease BEFREE A novel recombinant human thrombopoietin therapy for the management of immune thrombocytopenia in pregnancy. 28630121 2017
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Beyond immune thrombocytopenia: the evolving role of thrombopoietin receptor agonists. 28275823 2017
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Thrombopoietin-receptor-agonists (TPO-RAs) increase platelet production in Immune Thrombocytopenia (ITP) by stimulating Mpl. 27819522 2017
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Eltrombopag (thrombopoietin-receptor agonist) and plasmapheresis as rescue therapy of acute post-renal transplant immune thrombocytopenia in a child with Schimke immuno-osseous dysplasia-case report. 27671102 2016
Entrez Id: 4352
Gene Symbol: MPL
MPL 		0.100 Biomarker disease BEFREE Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia. 25132654 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.060 AlteredExpression disease BEFREE Indirubin regulates MPL and TNF expression in peripheral blood mononuclear cells from patients with primary immune thrombocytopenia. 31014934 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.060 GeneticVariation disease BEFREE Association Between TNF-α -308G/A Polymorphism and Risk of Immune Thrombocytopenia: A Meta-Analysis. 27960071 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.060 GeneticVariation disease BEFREE The polymorphisms of tumor necrosis factor-induced protein 3 gene may contribute to the susceptibility of chronic primary immune thrombocytopenia in Chinese population. 25806576 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.060 GeneticVariation disease BEFREE Association of TNF-α -308G>A and TNF-β +252A>G genes polymorphisms with primary immune thrombocytopenia: a North Indian study. 26761582 2016
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.060 GeneticVariation disease BEFREE TNF-α promoter single nucleotide polymorphisms and haplotypes associate with susceptibility of immune thrombocytopenia in Chinese adults. 25158149 2014
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.060 Biomarker disease BEFREE Single nucleotide polymorphism (SNP) analysis demonstrates a significant association of tumour necrosis factor-alpha (TNFA) with primary immune thrombocytopenia among Caucasian adults. 21756542 2011
Entrez Id: 112744
Gene Symbol: IL17F
IL17F 		0.040 GeneticVariation disease BEFREE Assessment of IL-17F rs763780 gene polymorphism in immune thrombocytopenia. 30594845 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.040 GeneticVariation disease BEFREE IL-10 polymorphisms and T-cell subsets could affect the clinical presentation and outcome of childhood immune thrombocytopenia in Egyptian population. 29696721 2018
Entrez Id: 112744
Gene Symbol: IL17F
IL17F 		0.040 GeneticVariation disease BEFREE Decreased Frequency of IL-17F rs763780 Site Allele G is Associated With Genetic Susceptibility to Immune Thrombocytopenia in a Chinese Population. 26620416 2017
Entrez Id: 112744
Gene Symbol: IL17F
IL17F 		0.040 GeneticVariation disease BEFREE Cytokine gene polymorphism [tumor necrosis factor-alpha (-308), IL-10 (-1082), IL-6 (-174), IL-17F, 1RaVNTR] in pediatric patients with primary immune thrombocytopenia and response to different treatment modalities. 27007229 2016
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.040 GeneticVariation disease BEFREE Cytokine gene polymorphism [tumor necrosis factor-alpha (-308), IL-10 (-1082), IL-6 (-174), IL-17F, 1RaVNTR] in pediatric patients with primary immune thrombocytopenia and response to different treatment modalities. 27007229 2016
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.040 Biomarker disease BEFREE Pulsed high-dose dexamethasone improves interleukin 10 secretion by CD5+ B cells in patients with primary immune thrombocytopenia. 22669326 2012
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.040 GeneticVariation disease BEFREE Interleukin-10 gene polymorphism reflects the severity of chronic immune thrombocytopenia in Japanese patients. 21463487 2011
Entrez Id: 112744
Gene Symbol: IL17F
IL17F 		0.040 GeneticVariation disease BEFREE Interleukin-17F gene polymorphism in patients with chronic immune thrombocytopenia. 21615796 2011