Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2875
Gene Symbol: GPT
GPT
0.090 AlteredExpression phenotype BEFREE Other predictors for ESLD were older age, being of Sub-Sahara African descent, increased alanine aminotransferase levels and hepatitis C virus coinfection. 30411848 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.090 Biomarker phenotype BEFREE Our findings strongly indicate that IAV coinfection compromises the host's ability to control Mtb infection via the production of IL-10 which was rapidly induced upon viral infection. 30998505 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.090 AlteredExpression phenotype BEFREE L. (L.) amazonensis and Phlebovirus coinfection potentiated PKR activation and synergistically induced the expression of IFNβ and IL-10. 31216268 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.090 Biomarker phenotype BEFREE Moreover, IL-10-producing tolerogenic DCs were remarkably induced by MAH and <i>P. aeruginosa</i> co-infection. 31440223 2019
Entrez Id: 2875
Gene Symbol: GPT
GPT
0.090 Biomarker phenotype BEFREE Anellovirus was highly prevalent (93.3%) and the co-infection with multiple genera (alpha, beta, and gammatorquevirus) were more common in the donors with normal ALT values in comparison to those with elevated ALT (single/double/triple Anellovirus genera, 1/3/24 vs. 7/7/14 or 6/7/13, p = 0.009). 31393615 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.090 Biomarker phenotype BEFREE This review briefly discusses patterns of selected cytokine (IL-6, IL-8, IL-10, TNF-α and INF-γ) responses associated with infections caused by Plasmodium, intestinal parasites as well as a Plasmodium-helminth co-infection. 29970128 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.090 Biomarker phenotype BEFREE Our findings further imply a convergent mechanism of inhibition of TLR signaling by <i>T. gondii</i> and IL-10 and suggest potential negative consequences of HIV/<i>T. gondii</i> coinfection. 29180487 2018
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.090 Biomarker phenotype BEFREE Instead, a combined deficiency in IL-4 and IL-10 was required to reverse the negative effects of helminth coinfection on the CD8 T cell response. 27956529 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.090 Biomarker phenotype BEFREE Antigens from the tapeworm Hymenolepis diminuta and the nematode Trichuris muris caused an anti-inflammatory response with M2-type polarization, reduced macrophage phagosome maturation and ability to activate T cells, along with increased Mtb burden, especially in T. muris exposed cells which also induced the highest IL-10 production upon co-infection. 28192437 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.090 Biomarker phenotype BEFREE An increase of messenger RNA (mRNA) expression of Th1- (IFN-γ, IL-12, TNF-α) and Th2-related cytokines (IL-10) mainly in groups PC-E and TE was observed, however, without statistically significant differences between co-infection and single infection with Eimeria. 28983740 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.090 GeneticVariation phenotype BEFREE Our findings suggest that common IL-10 (-1082, -819 and -592) genotypes/haplotypes do not influence the degree of HAI and response to combination therapy or susceptibility to HCV infection with and without S. mansoni co-infection. 19555400 2009
Entrez Id: 2875
Gene Symbol: GPT
GPT
0.090 GeneticVariation phenotype BEFREE In multivariable analyses, the following factors predicted an ALT level >50 IU/mL: log10 HCV RNA (OR, 1.15; 95% CI, 1.00 to 1.32); HIV co-infection (OR, 0.48; 95% CI, 0.25 to 0.89); and having ever been treated for HCV (OR, 1.92; 95% CI, 1.16 to 3.18). 17505167 2007
Entrez Id: 2875
Gene Symbol: GPT
GPT
0.090 AlteredExpression phenotype BEFREE Significance of hepatitis C virus coinfection with persistently normal alanine aminotransferase levels in HIV-1-infected patients. 15369515 2004
Entrez Id: 2875
Gene Symbol: GPT
GPT
0.090 AlteredExpression phenotype BEFREE Among those with mixed infection, a significant proportion (44.2%) of CH-B patients, had ALT levels greater than the upper limit of normal (ULN), as compared with the blood donor groups (16.6%; p = 0.036). 15230642 2004
Entrez Id: 2875
Gene Symbol: GPT
GPT
0.090 AlteredExpression phenotype BEFREE Furthermore, almost one third of the patients in the studied group was coinfected with transfusion-transmitted virus (TTV) and manifested significantly higher ALT levels (p = 0.020), and these were raised further if coinfection with TTV and human hepatitis C virus had occurred (p = 0.010). 12684549 2003
Entrez Id: 2875
Gene Symbol: GPT
GPT
0.090 Biomarker phenotype BEFREE The spectrum of liver disease in coinfection includes a significant proportion of patients with normal ALT values, and excluding these patients from previous studies has led to an overestimation of HCV disease severity. 12514411 2003
Entrez Id: 2875
Gene Symbol: GPT
GPT
0.090 AlteredExpression phenotype BEFREE Statistically significant univariate associations were observed between GBV-C-RNA positivity and younger age (P=0.006) and HCV-RNA positivity (P=0.024), as well as with higher serum alanine aminotransferase levels (P< 0.001); this latter association was shown to be independent of coinfection with HCV and of age by a multiple logistic regression model. 9783693 1998
Entrez Id: 2875
Gene Symbol: GPT
GPT
0.090 Biomarker phenotype BEFREE Furthermore, we studied the frequency of coinfection with hepatitis B virus (HBV) and/or hepatitis C virus (HCV) as well as a possible relationship to the alanine aminotransferase (ALT) status of the blood samples, taken at random from thalassaemic children who have received multiple blood transfusions and from volunteer blood donors. 9570237 1998
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.080 Biomarker phenotype BEFREE Macrophage mRNA expression for iNOS at 48 hpi and for TNF-α at 72 hpi were significantly elevated after mixed infection. 30081942 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.080 Biomarker phenotype BEFREE Polymicrobial infection utilizes the same mechanism as high-dose TNFα to elicit apoptosis-associated tissue damage of multiple organs. 29795446 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.080 Biomarker phenotype BEFREE An increase of messenger RNA (mRNA) expression of Th1- (IFN-γ, IL-12, TNF-α) and Th2-related cytokines (IL-10) mainly in groups PC-E and TE was observed, however, without statistically significant differences between co-infection and single infection with Eimeria. 28983740 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.080 Biomarker phenotype BEFREE We found that TNFα is likely to be the most sensitive biomarker reflecting inflammatory response during coinfection among three explored cytokines. 28740377 2017
Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
0.080 Biomarker phenotype BEFREE Additionally, we showed TRIMα and TRIM22 positively correlated with IFN-α, -β, which could be dysregulated by HIV, HCV mono- and co-infection. 26519943 2016
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.080 Biomarker phenotype BEFREE Additionally, we showed TRIMα and TRIM22 positively correlated with IFN-α, -β, which could be dysregulated by HIV, HCV mono- and co-infection. 26519943 2016
Entrez Id: 3447
Gene Symbol: IFNA13
IFNA13
0.080 Biomarker phenotype BEFREE These findings indicate that coinfection is associated with a type 1 IFN monocyte activation profile which was further found to correlate with cognitive impairment, even in subjects with controlled HIV infection. 23437063 2013