These observations suggested that the former ILC/DC profiles could be a predictor of a balanced cellular and humoral immune outcome.In addition, following i.n. delivery Rhinovirus (RV) and Adenovius type 5 (Ad5) vectors that induced elevated ILC2-derived IL-13, NKp46<sup>+</sup> ILC1/ILC3-derived-IFN-γ and no IL-17A, predominantly recruited CD11b<sup>-</sup> B220<sup>+</sup> plasmacytoid DCs (pDC).
Flow cytometry showed increased lineage-, NKp46-, RORγt+ IL-17+ILC3s and γδ T cells in the lungs of EV-D68-treated mice compared with those in RV-treated mice.
Furthermore, by using gene array analysis we discovered that targeted deletion of Il17a in murine lung CD4(+) T cells impaired Oas1g mRNA downstream of Ifnβ, independently from RV infection.