Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.330 GeneticVariation disease BEFREE We have tested the functional significance of BACE1 processing of APP using App-Swedish (App<sup>s</sup> ) knock-in rats, which carry an App mutation that causes familial Alzheimer's disease (FAD) in humans. 31496118 2019
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.330 Biomarker disease BEFREE The results demonstrate that APP673 regulates APP processing and the BACE1 cleavage site selection is critical for amyloidogenesis in AD pathogenesis, and implicate a pharmaceutical potential for targeting the APP673 site for AD drug development.<b>SIGNIFICANCE STATEMENT</b> β-site APP cleaving enzyme 1 (BACE1) is essential for amyloid β protein production. 28626014 2017
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.330 AlteredExpression disease BEFREE These data suggest that, selectively in neurons, relatively high levels of BACE1 activity lead to substrate pressure on FAD-mutant GS complexes, promoting CNS Aβ42 accumulation. 29141208 2017
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
0.330 Biomarker disease CTD_human Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. 16407166 2006