Gene: CASP3 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 836
Gene Symbol: CASP3
CASP3 		0.330 AlteredExpression disease BEFREE Familial Alzheimer disease (FAD) mutations suppress the ability of PS1 to promote PI3K/AKT signaling, prevent phosphorylation/inactivation of GSK-3 and promote activation of caspase-3. 18184791 2008
Entrez Id: 836
Gene Symbol: CASP3
CASP3 		0.330 Biomarker disease CTD_human Loss of phospholipid asymmetry and elevated brain apoptotic protein levels in subjects with amnestic mild cognitive impairment and Alzheimer disease. 18077176 2008
Entrez Id: 836
Gene Symbol: CASP3
CASP3 		0.330 Biomarker disease BEFREE Hypocapnia (20 mm Hg CO2 for 6 h) induced caspase-3 activation and apoptosis; the PS1Delta9 FAD mutation significantly potentiated these effects. 16908971 2004
Entrez Id: 836
Gene Symbol: CASP3
CASP3 		0.330 Biomarker disease BEFREE Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2. 11278424 2001