Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | Biomarker | disease | BEFREE | Retroviral integration site analysis and the fate of transduced clones in an MDR1 gene therapy protocol targeting metastatic breast cancer. | 17907967 | 2007 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Because transduction of hematopoietic stem cells with the multidrug resistance 1 (MDR1) gene might circumvent this problem, we conducted a pilot study of MDR1 gene therapy against metastatic breast cancer. | 17683514 | 2007 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | MDR1 is upregulated in many tumors.We have previously detected activation of the MDR1 upstream promoter in metastatic breast cancer cells. | 15986426 | 2005 | ||||
|
0.070 | Biomarker | disease | BEFREE | Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients. | 10430060 | 1999 | ||||
|
0.070 | Biomarker | disease | BEFREE | In a pilot chemoprotection trial, autologous CD34+ cells from patients with metastatic breast cancer were exposed to a replication-incompetent retroviral vector carrying MDR-1 cDNA and then reinfused after HDCT. | 9829734 | 1998 | ||||
|
0.070 | Biomarker | disease | BEFREE | Retroviral mediated transfer of the human multidrug resistance gene (MDR-1) into hematopoietic stem cells during autologous transplantation after intensive chemotherapy for metastatic breast cancer. | 7526902 | 1994 | ||||
|
0.070 | Biomarker | disease | BEFREE | Reduced occurrence of mdr-1 amplification in stage-IV breast-cancer patients treated with tamoxifen compared with other endocrine treatments. | 8094712 | 1993 |