Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE She presented with a clinical diagnosis of Li-Fraumeni-like syndrome (LFL), showing papillary thyroid carcinoma and fibrosarcoma of the left flank, and had no TP53 germline mutations. 25935441 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE The expression of wild-type and mutant p53 was studied in two fibrosarcoma cell lines in a mouse xenograft model. 17465229 2007
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 GeneticVariation disease BEFREE With the exception of one amino-acid substitution at position 280 (Arg-->Gln), the deduced amino-acid sequences of neutrophil gelatinase are identical to the amino-acid sequences of the enzyme isolated from fibrosarcoma cells. 8305481 1994
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.100 GeneticVariation disease BEFREE We treated mice bearing WEHI-164 fibrosarcoma with a combination of F8-TNF and doxorubicin, curing the majority of treated animals (29/37). 28484076 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE This approach has facilitated the identification of novel AT-rich interaction domain 1A gene mutations in ovarian clear cell carcinoma, frequent tumor protein 53 (<i>TP53</i>) gene mutations in high-grade ovarian serous carcinoma, and Kirsten rat sarcoma and B-rapidly accelerated fibrosarcoma proto-oncogene, serine/threonine kinase gene mutations in low-grade ovarian serous carcinoma. 28454214 2017
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 GeneticVariation disease BEFREE Accordingly, overexpression of a nonphosphorylable MT1-MMP mutant (Y573F) blocked sphingosine-1-phosphate-induced migration of Human umbilical vein endothelial cells and HT-1080 (human fibrosarcoma) cells and failed to stimulate migration of cells lacking the enzyme (bovine aortic endothelial cells). 17389600 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE These results suggest that MSI and p53 mutations are involved in tumor progression of DFSP to fibrosarcoma as early and late events, respectively. 14991543 2004
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.040 GeneticVariation disease BEFREE Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells. 28578659 2017
Entrez Id: 2130
Gene Symbol: EWSR1
EWSR1
0.040 GeneticVariation disease BEFREE Sclerosing epithelioid fibrosarcoma (SEF) is a rare fibrosarcoma variant with specific histomorphology and consistent translocation (EWSR1-CREB3L1/2). 25990776 2015
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.040 GeneticVariation disease BEFREE The IDH1 mutant fibrosarcoma secretome stimulated vascular-endothelial tube formation by ~138% relative to control. 30755816 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.040 GeneticVariation disease BEFREE Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells. 30355481 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.040 GeneticVariation disease BEFREE Here, using a genetically engineered inducible system, we report that selective suppression of endogenous mutant IDH1 expression in HT1080, a fibrosarcoma cell line with a native IDH1(R132C) heterozygous mutation, significantly inhibits cell proliferation and decreases clonogenic potential. 22885298 2012
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.030 GeneticVariation disease BEFREE In this study, to assess an involvement of LPA receptor genes in the development of human cancer cells, we looked for the presence of mutations in LPA receptor 1-6 (LPA1-6) genes in MG63 osteosarcoma, HT1080 fibrosarcoma, A549 lung adenocarcinoma, MCF-7 breast carcinoma, and G-361 melanoma cells. 21116120 2010
Entrez Id: 1277
Gene Symbol: COL1A1
COL1A1
0.030 GeneticVariation disease BEFREE Recently, the COL1A1-PDGFB chimeric gene resulting from a reciprocal translocation, t(17;22), and/or a supernumerary ring chromosome, r(17;22), has been identified, not only in conventional dermatofibrosarcoma protuberans (DFSP) but also in areas of DFSP with progression to fibrosarcoma (so-called fibrosarcomatous transformation) (FS-DFSP). 11329146 2001
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.030 GeneticVariation disease BEFREE The present study aimed to assess the B rapidly accelerated fibrosarcoma (BRAF<sup>V600E</sup>) status in plasma from Chinese patients with melanoma, and evaluated its prognostic value following treatment with BRAF inhibitors. 29434880 2018
Entrez Id: 5894
Gene Symbol: RAF1
RAF1
0.030 GeneticVariation disease BEFREE Reduced RB abundance, in turn, impairs E2F1 transcriptional inhibition, leading to increased peptidyl-prolyl cis-trans isomerase never-in-mitosis A (NIMA)-interacting 1 (PIN1) levels, human keratinocyte neoplastic cell transformation, and melanoma tumorigenesis via enhanced rapidly accelerated fibrosarcoma 1(RAF1)-MEK-ERK signaling pathway activation. 29750576 2018
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
0.030 GeneticVariation disease BEFREE Among these, compound <b>6b</b> induced a significant reduction in the expression level of CDK9 (cyclin-dependent kinase 9)/cyclin T1 in CFPAC-1 cells concomitant with attenuation of proliferative signaling mediated by c-Raf (rapidly accelerated fibrosarcoma) and p38 MAP (mitogen-activated protein) kinases. 29104242 2017
Entrez Id: 3716
Gene Symbol: JAK1
JAK1
0.030 GeneticVariation disease BEFREE To determine the role of the Janus tyrosine kinase (JAK)-STAT pathway in NF-kappaB activation by IFN, we examined NF-kappaB activation in JAK1-deficient mutant human fibrosarcoma cells. 15883164 2005
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.030 GeneticVariation disease BEFREE Similar targeting of BRAF(V599E) or wild-type BRAF in human fibrosarcoma cells that lack the BRAF(V599E) mutation does not recapitulate these effects. 14500344 2003
Entrez Id: 2720
Gene Symbol: GLB1
GLB1
0.030 GeneticVariation disease BEFREE To detect delayed activation of p53, we constructed a reporter plasmid containing the p53-responsible promoter and the bacterial beta-galactosidase (beta-gal) gene and introduced it into human fibrosarcoma (HT1080) cells, which retain wild-type p53 function. 12615706 2003
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
0.020 GeneticVariation disease BEFREE Sonication of xenograft HT1080 fibrosarcoma tumors released extracellular vesicles that contained detectable RAC1 mRNA with the highly tumorigenic N92I mutation known to exist in HT1080 cells. 27793845 2017
Entrez Id: 3052
Gene Symbol: HCCS
HCCS
0.020 GeneticVariation disease BEFREE A total of eight different human STS cell lines were used in the study: Fibrosarcoma (HT1080), liposarcoma (SW872, T778 and MLS‑402), synovial sarcoma (SW982, SYO1 and 1273) and pleomorphic sarcoma (U2197). 27909727 2017
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.020 GeneticVariation disease BEFREE Transfection of a human fibrosarcoma cell line with chloramphenicol acetyltransferase expression plasmids linked to a 5'-flanking deletion mutants of the IL-8 gene demonstrated that the nucleotides between -94 and -71 base pairs from the start of the first exon are essential and sufficient for the IL-8 induction by either IL-1, TNF, or phorbol 12-myristate 13-acetate. 2250017 1990
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.020 GeneticVariation disease BEFREE Detection of DNA abnormalities by arbitrarily primed PCR fingerprinting: amplification of the MDM2 gene in a mediastinum fibrosarcoma. 10329377 1999
Entrez Id: 6657
Gene Symbol: SOX2
SOX2
0.020 GeneticVariation disease BEFREE Here, we review the biological relevance of Sox2 and Sox9 genes in osteosarcoma, chondrosarcoma and chordoma; Sox2, Sox6, and Sox17 genes in Ewing's sarcoma; Sox2, Sox9, and Sox10 genes in synovial sarcoma; Sox2 gene in fibrosarcoma; and Sox21 gene in liposarcoma. 27138764 2016