Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 Biomarker disease BEFREE When MT1-MMP was silenced in HT1080 fibrosarcoma cells, cells created three dimensional (3D) fibronectin matrix in a confluent culture, and growth of cells embedded within it was retarded. 23756810 2013
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE Pinosylvin suppressed the expression of matrix metalloproteinase (MMP)-2, MMP-9 and membrane type 1-MMP in cultured human fibrosarcoma HT1080 cells. 21937212 2012
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE We found that overexpression of SMYD3 was sufficient to induce MMP-9 expression in transformed leukocytes and fibrosarcoma cells and that proinflammatory phorbol esters further enhanced this effect. 22194464 2012
Entrez Id: 8872
Gene Symbol: CDC123
CDC123
0.100 AlteredExpression disease BEFREE HIF-1α expression in HT 1080 human fibrosarcoma cells in vitro was silenced using HIF-1α siRNA sequence primers. 21437769 2011
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Herein, to determine the relationship between AKAP12 and MMP-9 in cancer, we first investigated the expression of MMP-9 under normoxic and hypoxic conditions in human fibrosarcoma cells. 21461577 2011
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.100 Biomarker disease BEFREE Interestingly, collagen XV was found to inhibit the adhesion and migration of fibrosarcoma cells when present in fibronectin-containing matrices. 20040604 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE In addition, the expression level of COX-2 was also increased by PFT-α in normal fibroblasts as well as in HT1080 fibrosarcoma cells with p53 wild-type cells. 21071999 2010
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 AlteredExpression disease BEFREE Inhibition of the expression on MMP-2, 9 and morphological changes via human fibrosarcoma cell line by 6,6'-bieckol from marine alga Ecklonia cava. 20132738 2010
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 Biomarker disease BEFREE Using the invasive human fibrosarcoma cell line HT-1080, we demonstrate that a plasma membrane SNARE, SNAP23, and an endosomal v-SNARE, VAMP3 (also known as cellubrevin), partly colocalize with MMP2 and MMP9, and that inhibition of these SNAREs using dominant-negative SNARE mutants impaired secretion of the MMPs. 19910495 2009
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE Using the invasive human fibrosarcoma cell line HT-1080, we demonstrate that a plasma membrane SNARE, SNAP23, and an endosomal v-SNARE, VAMP3 (also known as cellubrevin), partly colocalize with MMP2 and MMP9, and that inhibition of these SNAREs using dominant-negative SNARE mutants impaired secretion of the MMPs. 19910495 2009
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.100 AlteredExpression disease BEFREE Transfection of HT1080 cells with LC3 enhanced fibronectin mRNA translation. 19366727 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE Furthermore, anti-TNF activity was observed in inhibiting TNFalpha-mediated cytotoxicity in the murine L929 fibrosarcoma assay. 18547669 2008
Entrez Id: 8872
Gene Symbol: CDC123
CDC123
0.100 AlteredExpression disease BEFREE HIF-1 inhibition by chetomin effectively reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro. 17999771 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE The expression of wild-type and mutant p53 was studied in two fibrosarcoma cell lines in a mouse xenograft model. 17465229 2007
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE Inhibitory effect of chitooligosaccharides on matrix metalloproteinase-9 in human fibrosarcoma cells (HT1080). 17091328 2007
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Sulfated glucosamine inhibits MMP-2 and MMP-9 expressions in human fibrosarcoma cells. 17498959 2007
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 AlteredExpression disease BEFREE Sulfated glucosamine inhibits MMP-2 and MMP-9 expressions in human fibrosarcoma cells. 17498959 2007
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 GeneticVariation disease BEFREE Accordingly, overexpression of a nonphosphorylable MT1-MMP mutant (Y573F) blocked sphingosine-1-phosphate-induced migration of Human umbilical vein endothelial cells and HT-1080 (human fibrosarcoma) cells and failed to stimulate migration of cells lacking the enzyme (bovine aortic endothelial cells). 17389600 2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.100 Biomarker disease BEFREE The muteins were prepared as a soluble form by using a chaperonin co-expression system and the cytotoxic activities of the purified muteins were evaluated on TNF-sensitive murine fibrosarcoma L929 cells. 15703873 2005
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 AlteredExpression disease BEFREE Various mutants lacking the catalytic domain (dCAT) were prepared and confirmed to inhibit MT1-MMP activity in human fibrosarcoma HT1080 cells, and tumor cells expressing these mutants were implanted s.c. into nude mice to monitor tumor formation. 16093431 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE To learn more about its effect on cellular proliferation and chemoresistance independent of p53 up-regulation, human HT-1080 fibrosarcoma cells null for p14(ARF) and harboring a defective p53 pathway were stably transfected with p14(ARF) cDNA under the tight control of a doxycycline-inducible promoter. 15205349 2004
Entrez Id: 8872
Gene Symbol: CDC123
CDC123
0.100 AlteredExpression disease BEFREE Unexpectedly, in both murine embryonic fibroblasts (MEFs) and HT 1080 fibrosarcoma cells, LRP-1 expression was associated with increased levels of PDGF beta-receptor. 15486970 2004
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Collectively, these results suggest that simvastatin is a potent drug for inhibition of MMP-9 expression in osteoblastic cells and HT1080 fibrosarcoma cells. 15107580 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation disease BEFREE These results suggest that MSI and p53 mutations are involved in tumor progression of DFSP to fibrosarcoma as early and late events, respectively. 14991543 2004
Entrez Id: 8872
Gene Symbol: CDC123
CDC123
0.100 Biomarker disease BEFREE Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in HT 1080 fibrosarcoma cells. 12606037 2003