Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 AlteredExpression disease BEFREE Expression of T1<sup>Pr αMT1</sup> brings about a complete abrogation of the gelatinolytic activity of cellular MT1-MMP in HT1080 fibrosarcoma cells whilst in renal carcinoma cells CaKi-1, the GPI-TIMP causes a disruption in MMP-mediated proteolysis of ECM components such as fibronectin, collagen I and laminin that consequently triggers a downstream senescence response. 30641935 2019
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 Biomarker disease BEFREE Furthermore, the MMP-14 binding attributes of the active fusion protein were determined and its therapeutic efficacy against human esophageal carcinoma KYSE150 xenograft and human fibrosarcoma HT1080 xenograft models in nude mice was investigated. 26314845 2015
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 AlteredExpression disease BEFREE Our experimental data demonstrated that these two microRNAs inhibited the translation of mRNA of MT1-MMP and down-regulated its proteolytic enzyme activities via targeting 3'UTR of mRNA of MT1-MMP, further decreased activating proMMP2 into active MMP2 in fibrosarcoma HT1080, benign prostatic hyperplasia epithelial cell BPH-1 and glioblastoma U87GM. 25545756 2015
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 Biomarker disease BEFREE Fisetin dose-dependently inhibits proliferation of fibrosarcoma HT-1080 cells and human umbilical vascular endothelial cells (HUVECs), MMP-14-mediated activation of proMMP-2 in HT-1080 cells, invasiveness of HT-1080 cells, and in vitro tube formation of HUVECs. 24099040 2013
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 Biomarker disease BEFREE When MT1-MMP was silenced in HT1080 fibrosarcoma cells, cells created three dimensional (3D) fibronectin matrix in a confluent culture, and growth of cells embedded within it was retarded. 23756810 2013
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 GeneticVariation disease BEFREE Accordingly, overexpression of a nonphosphorylable MT1-MMP mutant (Y573F) blocked sphingosine-1-phosphate-induced migration of Human umbilical vein endothelial cells and HT-1080 (human fibrosarcoma) cells and failed to stimulate migration of cells lacking the enzyme (bovine aortic endothelial cells). 17389600 2007
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 AlteredExpression disease BEFREE Various mutants lacking the catalytic domain (dCAT) were prepared and confirmed to inhibit MT1-MMP activity in human fibrosarcoma HT1080 cells, and tumor cells expressing these mutants were implanted s.c. into nude mice to monitor tumor formation. 16093431 2005
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 AlteredExpression disease BEFREE We used RNA silencing technology to downregulate the endogenous MT1-MMP expression in human tumor cells (fibrosarcoma HT1080 and gastric carcinoma MKN-28 cell lines), and evaluated the effect on the invasion of a reconstituted basement membrane (Matrigel). 14647466 2003
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 Biomarker disease BEFREE A fibrosarcoma cell line transfected with the matrix metalloproteinase MT1 MMP showed an enhanced ability to degrade 14C-labelled collagen films. 11240131 2001
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 AlteredExpression disease BEFREE The presence of MT1-MMP oligomers also was shown for the enzyme naturally expressed in HT1080 fibrosarcoma cells. 11335709 2001
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 AlteredExpression disease BEFREE We demonstrated that anterior lens capsule type IV collagen or specifically the synthetic peptide alpha3(IV) 185-203 inhibited both the migration of melanoma or fibrosarcoma cells as well as the activation of membrane-bound MMP-2 by decreasing the expressions of MT1-MMP and the beta3 integrin subunit. 10667602 2000
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 Biomarker disease BEFREE We investigated the effect of hyperthermia on the production of MT1-MMP in human fibrosarcoma HT-1080 cells. 10548512 1999
Entrez Id: 4323
Gene Symbol: MMP14
MMP14
0.100 AlteredExpression disease BEFREE These findings suggest that the increased expression of E1AF in fibrosarcoma contributes to invasive phenotypes including MT1-MMP expression and enhanced cell migration, but not sufficient for exhibiting highly metastatic activity in vivo. 10208438 1999