| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | disease | BEFREE | In 2008, the discovery of ALK activating mutations in neuroblastoma, a tumor of the sympathetic nervous system, represented a breakthrough in the understanding of the pathogenesis of this pediatric cancer and established mutated ALK as a tractable therapeutic target for precision medicine. | 29374774 | 2018 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | <b>Purpose:</b> Anaplastic lymphoma kinase (<i>ALK</i>) is the most frequently mutated oncogene in the pediatric cancer neuroblastoma. | 27986745 | 2017 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Activating mutations of the ALK gene have been identified in sporadic and familial cases of neuroblastoma (NB), a cancer of the peripheral nervous system, and are thought to be the primary mechanism of oncogenic activation of this receptor in this pediatric neoplasm. | 23139213 | 2013 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase aberrantly expressed in neuroblastoma, a devastating pediatric cancer of the sympathetic nervous system. | 22266870 | 2012 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | Point mutations and amplification of the ALK gene occur in the childhood cancer neuroblastoma. | 20451371 | 2010 | ||||
|
0.070 | Biomarker | disease | BEFREE | Thus, while anaplastic lymphoma kinase-positive ALCL and young patient age generally are associated with a favorable prognosis, leukemic involvement seems to identify a high-risk malignant neoplasm that requires more aggressive therapy, including hematopoietic stem cell transplantation. | 14560573 | 2003 | ||||
|
0.070 | Biomarker | disease | BEFREE | Owing to the recent progress in understanding its pathogenesis, ALK+ TCL has become a model malignant neoplasm in which morphology-based diagnosis and classification are gradually shifting toward biology-based diagnosis. | 14569815 | 2002 |