Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE Indeed, the lack of CD5 and expression of CD10 associated with MYC rearrangement detected on interphasic nuclei could support the diagnosis of diffuse large B-cell lymphoma or Burkitt lymphoma. 23313364 2013
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE Unlike DH-BCL2/MYC lymphomas, however, they are more likely to be CD10(-) but IRF4/MUM-1(+) (P=0.03) and, more like BL, only infrequently express BCL2 (P<0.001), and are cytogenetically less complex (P<0.04). 23348205 2013
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE The expression of CD10 and BCL6 but not BCL2, a high Ki-67 PI (>90%) and a C-MYC rearrangement but not BCL2 or BCL6 rearrangement are the features of BL. 21740296 2011
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 GeneticVariation disease BEFREE We evaluated 35 BLs and identified atypical immunophenotypes in 4 including SIg light chain negativity in 4, negativity for B-cell antigens in 2, lack of CD10 in 1, and CD4 expression in 1. 20551277 2010
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE We suggest that, concordant with the WHO classification to be published in 2008, the diagnosis of BL should be restricted to cases with expression of CD10 and BCL6, absence or very weak expression of BCL2 protein, a homogeneously very high proliferation index and a proven IG-MYC translocation without evidence of a chromosomal translocation typical for other lymphoma entities. 18923440 2009
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE We can confidently distinguish BL from DLBCL-HPSS by using histopathologic and immunohistochemical (CD10, bcl-2, bcl-6, Ki-67) methods without the aid of EBER and FISH in the great majority of cases. 17875505 2007
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE In two of the three BLs lacking CD10 expression, no breakpoint could be detected, suggesting that CD10 is a discriminative marker of BL. 15034863 2004
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE Retrospective work-up of the 29-year-old tumor blocks revealed the typical histologic appearance and phenotype (CD20, CD10, BCL-6 positive) of Burkitt's lymphoma (BL) with a proliferation rate of 95%. 15291367 2004
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 GeneticVariation disease BEFREE In addition, CD10+, Bcl-2-, and low frequency of mutation of the VH gene could be helpful for the histologic distinction of BL from (c-mycR) DLBCL. 12118116 2002
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 GeneticVariation disease BEFREE TIMP-1-negative cells express the phenotype associated with group I BL lines and Epstein-Barr virus (EBV)-negative, nonendemic BLs (CD10+, CD38+, sIg+, and CD77+). 9694723 1998
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE A collection of in vitro EBV-converted sublines of originally EBV-negative BLs that expressed a full set of the growth transformation-associated EBV proteins maintained their CD10 and cyclin D3 expression. 8959341 1996
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE BALM-13 was characterized as belonging to the Burkitt lymphoma group III cell type (CD10-, CD20+, CD23+, D39+, CD77-), and BALM-14 to the Burkitt lymphoma group I cell type (CD10+, CD20+, CD23-, CD39-, CD77+). 9183631 1996
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE Unlike that observed in certain Burkitt lymphoma (BL) cell lines that share the same surface phenotype (CD10+CD38+CD23-CD39-), the c-myc-transfected cells expressed lymphocyte function-associated (LFA) 1, LFA-3, and intercellular adhesion molecule 1 and grew in large clumps rather than single-cell layers. 7836923 1995
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE Epstein Barr virus (EBV) positive and negative Burkitt's lymphoma (BL) cell lines showed heterogenous IL-10 expression: BL cell lines with a nonactivated germinal center phenotype (CD10+, CD77+, CD23-, CD30-, CDw70-) expressed little or no IL-10, whereas EBV-positive and negative BL cell lines with an activated phenotype (CD77-, CD23+, CD30+, CDw70+) expressed easily detectable amounts of IL-10 mRNA. 7694007 1993
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE TP-specific transcripts were not detectable or only hardly detectable in Burkitt's lymphoma cells with the group I phenotype (CD10+ CD77+ CD21- CD23- CD30- CDw70-) as well as in P3HR1 virus-converted Burkitt's lymphoma lines. 1845900 1991
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE The germinal centre specific MoAbs CD10 and CD77 (Burkitt's lymphoma antigen) displayed a heterogeneous pattern of reactivity and allowed to identify 4 subgroups: CD10+/CD77+ (44 per cent), CD10+/CD77- (15 per cent), CD10-/CD77+ (36 per cent) and CD10-/CD77- (5 per cent). 2210691 1990
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 Biomarker disease BEFREE Clones retaining the original BL biopsy cell phenotype (CD10/CD77-positive, activation antigen/adhesion molecule-negative) expressed the virus-encoded nuclear antigen EBNA 1 but not any of the other known latent proteins, EBNAs 2, 3a, 3b, 3c, -LP and latent membrane protein (LMP). 2165133 1990
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE Other activation antigens were unaffected by EBNA-2 expression, as were markers already expressed on the parent BL cell line, including BL markers (cALLA and BLA), proliferation markers (transferrin receptor and BK19.9), and cell adhesion-related molecules (LFA-1 and LFA-3). 3033649 1987
Entrez Id: 4311
Gene Symbol: MME
MME
0.100 AlteredExpression disease BEFREE In contrast with acute lymphoblastic leukemia, the common acute lymphocytic leukemia antigen (CD10) was expressed on nearly all BL cell lines of intermediate maturation stages but only on half of the pre-B ones. 3027441 1987