Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 AlteredExpression disease BEFREE JHU-083 treatment caused decreased growth and increased apoptosis in human MYC-expressing medulloblastoma cell lines. 31340195 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE This study highlights B7-H3 as a viable target in MB angiogenesis, and that the expression of miR-29 can inhibit B7-H3 and sensitize MB cells to treatment with MYC-inhibiting drugs. 31382461 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE Combined functional genomic and chemical screens identify SETD8 as a therapeutic target in MYC-driven medulloblastoma. 30626740 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 AlteredExpression disease BEFREE High MYC mRNA expression and MYC gene amplification in MB have been considered as indicators of poor prognosis. 30901604 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE Therefore, our data provide insights about the mechanisms underlying BETi effects and the appearance of resistance and support the therapeutic use of combined cell-cycle inhibitors with BETi in MYC-amplified medulloblastoma. 31160565 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 AlteredExpression disease BEFREE Critically, G207 delivered to the cerebellum was able to target/treat the highly aggressive MYC-overexpressed group 3 murine medulloblastoma increasing survival vs controls. 30918335 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE Expression and association between PRMT5 and MYC in primary medulloblastoma tumors were investigated using publicly available databases. 31694585 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE MK-8628 showed therapeutic efficacy against in vitro and in vivo models of MYC-amplified medulloblastoma by inducing apoptotic cell death and cell cycle arrest. 30611741 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE We find that higher MYC levels are associated with increased EZH2, and pharmacological blockade of EZH2 is a potential therapeutic strategy for aggressive medulloblastoma with elevated MYC. 30632221 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 AlteredExpression disease BEFREE We performed analysis of GABR and MYC expression in MB tumors and used molecular, cell biological, and whole-cell electrophysiology approaches to establish presence of a functional 'druggable' GABA<sub>A</sub>R in group 3 cells. 30725256 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE Most children with medulloblastoma fall within the standard-risk clinical disease group defined by absence of high-risk features (metastatic disease, large-cell/anaplastic histology, and MYC amplification), which includes 50-60% of patients and has a 5-year event-free survival of 75-85%. 30392813 2018
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE Human MYC-amplified (Med8A and D283) and non-amplified (UW228-2 and ONS76) MB cell lines were incubated for 2, 4 or 6 h with increasing doses (0-100 μg/ml) of 5-ALA, and PPIX accumulation was determined by flow cytometry. 30445362 2018
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 AlteredExpression disease BEFREE The BET inhibitor JQ1 suppressed MYC expression in a human G3 MB cell line (HD-MB03) and CRISPR-Myc, but not in Retro-Myc MBs. 29880921 2018
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 GeneticVariation disease BEFREE In addition, the combination treatment significantly prolonged survival as compared to single-agent therapy in orthotopically transplanted human Group 3 MB with MYC amplifications. 29511348 2018
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 AlteredExpression disease BEFREE In cell lines, SHH MB, which are low-MYC expressing, demonstrated both constitutive and inducible expression of PD-L1 while those in Group 3/4 that expressed high levels of MYC had only inducible expression. 29721192 2018
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE Results also demonstrated that the MYC-amplified MB lines showed a higher sensitivity to combined therapies compared to non-MYC-amplified cell lines. 29682173 2018
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 PosttranslationalModification disease BEFREE Functional analysis of enriched pathways highlighted cell-cycle progression and protein synthesis as therapeutic targets for MYC-like medulloblastoma. 29562177 2018
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE Furthermore, combination therapy with S3-NTDi and cisplatin significantly decreased highly aggressive MYC-amplified MB cell growth and induced apoptosis by downregulating STAT3 regulated proliferation and anti-apoptotic gene expression. 29280516 2018
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 AlteredExpression disease BEFREE TEAD4's co-activator, YAP1, and the downstream targets, MYC and CCND1, were also found to be upregulated in AT/RT when compared to medulloblastoma. 27966820 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE To identify targetable vulnerabilities, we employed inhibitor screening that revealed mTOR inhibitor hypersensitivity in the MYC-overexpressing medulloblastoma cell line, D341. 28409891 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells. 28504719 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE In line with these findings we show for MYC-amplified medulloblastoma a profound reduction in activity of the oncogenes STAT3 and AKT. 28159923 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE In parallel, studies of key factors responsible for cell autonomous growth in MYC amplified medulloblastoma prioritized IGF1R inhibitors. 27255663 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE DiSCoVER analysis predicted that aggressive MYC-driven Group 3 medulloblastoma would be sensitive to cyclin-dependent kinase (CDK) inhibitors. 27012813 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.400 Biomarker disease BEFREE Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological variables pertaining to age, presence of metastases, extent of resection, histological subtypes and in some instances individual genetic aberrations such as MYC and MYCN amplification. 27040285 2016