| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | disease | BEFREE | In vitro analyses revealed significant effects on viability in hTERT-mutated meningioma cells after targeted treatment. | 30788677 | 2019 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Mutations in the telomerase reverse transcriptase (TERT) gene promoter are comparably rare in meningioma, but were recently suggested to predict risk of recurrence and progression. | 30010853 | 2018 | ||||
|
0.080 | PosttranslationalModification | disease | BEFREE | In meningiomas, prognostic impact of mutations in the human telomerase reverse transcriptase (hTERT) promoter region was recently shown, while studies of promoter methylation and analyses of hemangiopericytomas are lacking. hTERT promoter methylation was analyzed in 78 meningioma and 38 meningeal hemangiopericytoma samples by methylation-specific polymerase chain reaction (MS-PCR) and compared with histopathological and clinical variables and with immunohistochemical hTERT expression. | 27465278 | 2016 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The TERT C228T or C250T mutation was found in 33/35 (94 %) of established malignant glioma cell lines and both meningioma cell lines examined. | 26960334 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | Establishment of an in vivo meningioma model with human telomerase reverse transcriptase. | 17415213 | 2007 | ||||
|
0.080 | Biomarker | disease | BEFREE | We have developed a meningioma cell line by retrovirally transducing primary cells derived from a human WHO grade I meningothelial meningioma with the human telomerase reverse transcriptase (hTERT) gene, which enables bypassing cellular senescence. | 15965488 | 2005 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We have previously described telomerase activity or expression of the telomerase catalytic subunit hTERT in this meningioma series. | 11859969 | 2001 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Telomerase activity and expression of the telomerase catalytic subunit, hTERT, in meningioma progression. | 10794298 | 2000 |