Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Examination of SNP309 in glioblastoma patients showed a borderline association with survival but no apparent correlation with age at diagnosis nor with TP53 and p14(ARF) status of their tumours. 18781178 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Co-immunoprecipitation assays revealed a ternary complex among NF2, T-antigen, and the tumor suppressor protein, p53 within a glioblastoma cell line. 23308224 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Resveratrol targeting of AKT and p53 in glioblastoma and glioblastoma stem-like cells to suppress growth and infiltration. 27419830 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE This antagonism results in increased p53 activity and can also re-activates the p53 pathway and resensitize the glioblastoma cells to apoptosis. 30656973 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 AlteredExpression disease BEFREE Prolonged temozolomide for treatment of glioblastoma: preliminary clinical results and prognostic value of p53 overexpression. 21725801 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 AlteredExpression disease BEFREE In this study, we show that the expression of both wild-type p53 and MDM2 (murine double minute 2) proteins was induced when cis-diamminedichloroplatinum (cisplatin) caused apoptosis in human glioblastoma U87-MG cells, which expressed neither wild-type p53 nor MDM2 protein prior to treatment. 7761100 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE These data challenge the view of p53 as an angiogenesis-regulator in glioblastoma in that relevant signaling pathways are silenced, potentially contributing to the angiogenic switch during malignant progression. 20504876 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Impairment of IMPDH2 activity triggers nucleolar stress and growth arrest of glioblastoma cells even in the absence of functional p53. 31371825 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Alkylaminophenol Induces G1/S Phase Cell Cycle Arrest in Glioblastoma Cells Through p53 and Cyclin-Dependent Kinase Signaling Pathway. 31001122 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Results suggested that aberrations of the p53 gene were not correlated with the malignancy of some types of brain tumors such as anaplastic astrocytoma and glioblastoma, contrary to previous observations on colorectal cancers. 1886708 1991
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE The Effect of Sodium Valproate on the Glioblastoma U87 Cell Line Tumor Development on the Chicken Embryo Chorioallantoic Membrane and on EZH2 and p53 Expression. 28642877 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE The effects of an acidic condition (pH 6.5) on WAF1 gene expression and p53 accumulation was investigated in human glioblastoma cells with different p53 statuses. 9307270 1997
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE This glioblastoma subtype develops clinically de novo after a short clinical history and contains a high frequency of p53 mutations. 10068201 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE The role of apoptosis, cell proliferation index, bcl-2, and p53 in glioblastoma prognosis. 15235729 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 AlteredExpression disease BEFREE A human glioblastoma cell line with repressible expression of the p53 protein did not show any difference in MTH-68/H sensitivity in its p53-expressing and p53-depleted states, indicating that the apoptotic process induced by MTH-68/H does not depend on p53. 17215292 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE The impact of arsenic trioxide and all-trans retinoic acid on p53 R273H-codon mutant glioblastoma. 24399651 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE However, clear positive effects were seen in a p53 proficient glioblastoma line (U87) when the cells were grown under serum free conditions, while no effects were found in p53 deficient glioblastoma cells (U251). 29649215 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE These results demonstrate the efficiency of using exogenous wild type p53 to suppress glioblastoma cell with endogenous wild type p53 in vivo through liposome mediated transfection method. 9144539 1997
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE We studied the radiation response of the U-87 MG human glioblastoma cell line and transfected derivatives in which p53 function had been inactivated. 8564961 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Temozolomide Treatment Induces lncRNA MALAT1 in an NF-κB and p53 Codependent Manner in Glioblastoma. 30940658 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE A stereotactic core biopsy revealed glioblastoma with immunostaining suggestive of histone H3K27M and TP53 mutation, consistent with diffuse intrinsic pontine glioma. 28084680 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Here we report time-related changes and cell line specific patterns of gene expression after CPT treatment by using two p53 wild-type glioblastoma cell lines, U87-MG and DBTRG-05, with different sensitivities to TopoI inhibition. 18694480 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE A trend of inverse relationship between patient survival and the number of tumor cell nuclei with immunohistochemically detectable p53 protein was seen in glioblastoma cases: 20.5 +/- 12.7 versus 13.7 +/- 6.3 months (mean +/- SD) in instances with > or > or = 25% positive cells, respectively. 9266149 1997
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Quantitative morphological tumor characteristics on post-contrast T1-weighted MRI can to a certain degree provide insights regarding Ki67 and p53 status in patients with glioblastoma. 31020343 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Here, we reassessed this issue using a glioblastoma cell line (LN382) that expresses an endogenous temperature-sensitive mutant p53. 11668476 2001