Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE This glioblastoma subtype develops clinically de novo after a short clinical history and contains a high frequency of p53 mutations. 10068201 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE The impact of arsenic trioxide and all-trans retinoic acid on p53 R273H-codon mutant glioblastoma. 24399651 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE A stereotactic core biopsy revealed glioblastoma with immunostaining suggestive of histone H3K27M and TP53 mutation, consistent with diffuse intrinsic pontine glioma. 28084680 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Here, we reassessed this issue using a glioblastoma cell line (LN382) that expresses an endogenous temperature-sensitive mutant p53. 11668476 2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.300 GeneticVariation disease BEFREE Our data did not support our original observations relating individual IL-4Ralpha, IL-13, or COX-2 SNPs to glioblastoma risk. 18006935 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Mean Ki-67 labeling index was 29% (range, 1.5%-80%). p53 mutation was present in 20/36 GBs (55%), whereas OLIG2 expression was positive in 29/36 GBs (80.5%). 31003026 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Our data suggest that dominant-negative p53 mutants accelerate development and/or growth of glioblastoma anlagen. 10519380 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE While CT did not impact on the release of Hsp70, fractionated RT resulted in significantly increased extracellular concentrations of Hsp70 in p53 mutated and WT glioblastoma cells. 24678590 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE The present case is unusual in four aspects: (i) it arose from a low-grade ganglioglioma in the absence of previous radiation or chemotherapy, which is the fourth reported case; (ii) the original tumor showed a high proliferative index on flow cytometry but a low Ki-67 labeling index, implying that the application of flow cytometry might play a certain role in predicting biological and clinical behavior of low grade gangliogliomas; (iii) p53 mutation and deletion appeared in the secondary glioblastoma, which was not shown in the original well-differentiated ganglioglioma; and (iv) the transformed glioblastoma showed p16 inactivation detected by methylation and deletion, which are relatively uncommon genetic events in secondary glioblastomas. 14629754 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Synthetic small interfering RNA was used to knock down mutant TP53 in T98G and U138 cells, which are human glioblastoma cells with a P53 mutation, by screening of exons 4-8. 24248532 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Even though TP53 mutations were more frequent among younger patients with glioblastoma, they had no statistically significant effect on survival after adjustment for age (P = 0.62). 12173338 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE This suggests that the acquisition of TP53 mutations in these glioblastoma subtypes occurs through different mechanisms. 15466178 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Wortmannin sensitizes human glioblastoma cell lines carrying mutant and wild type TP53 gene to radiation. 11090962 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Progression of low-grade astrocytomas to anaplastic astrocytoma or glioblastoma occurred at a similar frequency in lesions with (79%) and without (63%) p53 mutations (P = 0.32), indicating that this genetic alteration is associated with tumor recurrence but not predictive of progression to a more malignant phenotype. 9815715 1997
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Mutations of the p53 gene were detected in four of the 23 astrocytomas (one glioblastoma and three anaplastic astrocytomas). 10063271 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Unusual findings include: TP53 mutation in a juvenile pilocytic astrocytoma; TP53 and PTEN mutations in a de novo glioblastoma, a gliosarcoma with identical mutations in gliomatous and sarcomatous components, and an infratentorial anaplastic astrocytoma with an earlier supratentorial grade II astrocytoma bearing the same TP53 mutation but not the PTEN mutation or loss of heterozygosity (LOH) of 10q23. 11355303 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE GSTT1 deletion was nearly significantly more common among glioblastoma cases with tumor p53 mutation than for those whose tumors did not have p53 mutation (OR 2.8; 95% CI 0.93-8.4; P = 0.07). 15006924 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE The aim of this study was to verify the frequency and clinical significance of the aneuploidy of chromosomes 7 and 10, EGFR amplification, PTEN and TP53 deletions and 1p/19q deficiency in adult patients diagnosed with glioblastoma. 28856550 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE This suggests the potential application of combined PB and radiotherapy in glioblastoma harboring mutant p53. 17707275 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Comparisons of tumor suppressor p53, p21, and p16 gene therapy effects on glioblastoma tumorigenicity in situ. 11549271 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Fifty-two percent of patients diagnosed with glioma/glioblastoma with a positive TP53 mutation had at least one concurrent mutation in a known pathogenic gene of which 9% were CDKN2A, 41% were IDH1, and 11% were PIK3CA. 29454261 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE We found that genetic alteration of the p53 pathway is a primary molecular event predictive of a high number of subclonal mutations in glioblastoma. 25650244 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE G:C-->A:T mutations at CpG sites were more frequent in secondary than primary glioblastomas, suggesting that the acquisition of TP53 mutations in these glioblastoma subtypes may occur through different mechanisms. 15977639 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE These data indicate that overexpression of the EGF receptor and mutations of the p53 tumor suppressor gene are mutually exclusive events defining two different genetic pathways in the evolution of glioblastoma as the common phenotypic endpoint. 8864278 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Analysis of the TP53 gene in laser-microdissected glioblastoma vasculature. 12624785 2003