Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1
Gene Symbol: A1BG
A1BG
0.020 Biomarker disease BEFREE The results show that combination of negative modulation of GA isoforms arising from GLS gene with the introduction of the GLS2 gene product, GAB, may in the future provide a useful means to curb glioblastoma growth in situ. 24096582 2014
Entrez Id: 1
Gene Symbol: A1BG
A1BG
0.020 Biomarker disease BEFREE Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway. 30669455 2019
Entrez Id: 17
Gene Symbol: AAVS1
AAVS1
0.010 Biomarker disease BEFREE The latter is of particular interest because the AAV integration site (AAVS1) is located on the long arm of chromosome 19 and 30-40% of human glioblastoma tumors are reported to have loss of heterozygosity in this region of chromosome 19q. 12542846 2002
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.020 Biomarker disease BEFREE We synthesized four candidate i-FAMPs, i-FAMP-D1, -D2, -D3 and -D4, and examined which i-FAMP has greater cholesterol efflux capacity than FAMP in A172 human glioblastoma cells transiently transfected with human ABCA1 cDNA. 31519377 2019
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.020 AlteredExpression disease BEFREE LXRβ gene expression poorly correlates with ABCA1 in glioblastoma patients, and expression of each gene correlates with poor patient prognosis in different prognostic subtypes. 31664073 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE DTA0100 mitotic arrest properties were investigated in two multi-drug resistant cancer cell lines with P-glycoprotein overexpression (colorectal carcinoma and glioblastoma). 28502672 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Here, we examined the role of the multidrug resistance (mdr) mechanism in the chemo-resistance of these tumors, using a twofold approach: (i) by assessing a possible mdr phenotype before and after chronic drug exposure of glioma cells in vitro, and (ii) by assessing the modulation of expression of the mdr-associated P-glycoprotein (Pgp) using radiotherapy and serial cycles of chemotherapy in human glioblastoma patients in vivo. 10805101 2000
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE We examined the effects of sulfinosine (SF), a quite unexplored purine nucleoside analog, in MDR (P-gp over-expressing) non-small cell lung carcinoma (NSCLC) and glioblastoma cell lines (NCI-H460/R and U87-TxR, respectively). 23326571 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE Interestingly, ABCB1 levels of expression diminished in SF188. 18946672 2009
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE In this report, we show that the mdm2 (murine double minute 2) gene induced the expression of the mdr1 gene and P-gp in human glioblastoma U87-MG cells, which did not express the MDM2 protein or P-gp. 8883415 1996
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation disease BEFREE Although the C3435T polymorphism does not appear to be associated with other types of glioma, we cannot rule out that this MDR1 polymorphism may be associated with glioblastoma among men. 15947495 2005
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Finding effective and safe inhibitors of Pgp that improve drug delivery across the BBB and target GB SC is open to investigation. 31265310 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE The aim of the present investigations was to reduce the expression of P-gp in the human glioblastoma cell line U-87 MG and in the human endothelial cell line HUV-ECC. 15051924 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation disease BEFREE ABCB1 single-nucleotide variants and survival in patients with glioblastoma treated with radiotherapy concomitant with temozolomide. 31624332 2020
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE In conclusion, continuous PTX treatment caused the over-expression of P-gp and acquisition of MDR in colon cancer and glioblastoma cell lines, while some mechanisms of MDR and tumor progression such as GSH detoxification system and VEGF secretion were suppressed. 21775090 2011
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. 28019039 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE Brain vessels extracted from tissue sections of nonmalignant human brain and glioblastoma tumors by laser capture microdissection microscopy and analyzed by real-time polymerase chain reaction showed higher expression of ABCG2 relative to ABCB1/MDR1 and ABCC1/MRP1. 12958161 2003
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE This novel mechanism of action, via the interaction of CAXII and Pgp, ultimately blocks the efflux function of Pgp to improve glioblastoma patient outcomes. 30254183 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-κB pathway in multidrug-resistant glioblastoma cells in vitro. 25823028 2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE We found that Wnt3a and ABCB1, which encodes for Pgp, were both highly expressed in glioblastoma stem cells and reduced by temozolomide. 23897632 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE We used genetically engineered spontaneous glioblastoma mouse models and allograft models that were orthotopically transplanted into wild-type (WT) and Abcb1/Abcg2-deficient (KO) recipients. 24647572 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE NQO may be a priority target of glioblastoma chemotherapy suitable for biochemical nature of the cells, and expression analysis of NQO1, alpha-TUB, beta-TUB, MGMT, MDR1 and GSTpi may help to seek a truly active drug against glioblastomas. 10639573 2000
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE We have compared the effect on the expression of P-glycoprotein (Pgp), the MDR1 gene product, on vinblastine resistance in two glioblastoma lines, U87 and U251, grown as either monolayers or spheroids. 9413166 1998
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE Enhanced MDR1 expression and chemoresistance of cancer stem cells derived from glioblastoma. 19832037 2009
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE CD133 (stem marker) and drug resistant gene (mdr1 and bcl-2) expression were detected in human glioblastoma and normal brain tissues. 18568776 2008