Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease MGD
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.100 AlteredExpression disease BEFREE <b>Abbreviations</b>: AAAIR: Average Annual Age-Adjusted Incidence Rate; AI/AN: American Indian or Alaska Native; API: Asian or Pacific Islander; CBTRUS: Central Brain Tumor Registry of the United States; CUMC: Columbia University Medical Center; EOR: Extent of Resection; Exc: Excluded; GBM: Glioblastoma; GTR: Gross Total Resection; IDH-1: Isocitrate Dehydrogenase 1; MGMT: O6-Methylguanine DNA Methyltransferase; NCDB: National Cancer Database; OS: Overall Survival; O/U: Other/Unknown; PFS: Progression-Free Survival; SEER: Surveillance, Epidemiology, and End Results; S&W BTR: Scott & White Brain Tumor Registry; UCLA: University of California Los Angeles; UM: University of Miami. 31271539 2019
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.100 Biomarker disease BEFREE <b>Abbreviations</b>: CGGA: Chinese Glioma Genome Atlas; TCGA: The Cancer Genome Atlas; TAMs: Tumor associated macrophages; IDH: isocitrate dehydrogenase; GBM: glioblastoma. 31143523 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.100 Biomarker disease BEFREE <b>Abbreviations</b>: CGGA: Chinese Glioma Genome Atlas; TCGA: The Cancer Genome Atlas; TAMs: Tumor associated macrophages; IDH: isocitrate dehydrogenase; GBM: glioblastoma. 31143523 2019
Entrez Id: 7474
Gene Symbol: WNT5A
WNT5A
0.100 Biomarker disease BEFREE <b>Background:</b> Wnt5a is a nontransforming Wnt family member and identified as an oncogenic role on cell motility of breast cancer and glioblastoma. 31114334 2019
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
0.100 Biomarker disease BEFREE <b>Conclusion:</b> High radiation doses to ipsilateral NSC and contralateral SVZ could have a negative impact on overall survival in IDH-wild-type glioblastoma population. 30338243 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.100 Biomarker disease BEFREE <b>Conclusion:</b> High radiation doses to ipsilateral NSC and contralateral SVZ could have a negative impact on overall survival in IDH-wild-type glioblastoma population. 30338243 2018
Entrez Id: 6657
Gene Symbol: SOX2
SOX2
0.100 Biomarker disease BEFREE <b>Objective:</b> Our aim is to study the prognostic value of stem cell markers (CD44, Nestin, Olig2 and SOX2) in a series of homogeneously treated GBs. 31496301 2019
Entrez Id: 3320
Gene Symbol: HSP90AA1
HSP90AA1
0.070 Biomarker disease BEFREE <b>Purpose:</b> HSP90, a highly conserved molecular chaperone that regulates the function of several oncogenic client proteins, is altered in glioblastoma. 28679777 2017
Entrez Id: 7465
Gene Symbol: WEE1
WEE1
0.060 GeneticVariation disease BEFREE <b>Purpose:</b> AZD1775, a first-in-class, small-molecule inhibitor of the Wee1 tyrosine kinase, is under evaluation as a potential chemo- and radiosensitizer for treating glioblastoma. 28928160 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 GeneticVariation disease BEFREE <b>Purpose:</b> The epidermal growth factor receptor variant III (<i>EGFRvIII</i>) mutation has been considered a driver mutation and therapeutic target in glioblastoma, the most common and aggressive brain cancer. 28428190 2017
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.100 AlteredExpression disease BEFREE <b>Purpose:</b> The PI3K-AKT-mTOR signaling pathway is frequently activated in glioblastoma and offers several druggable targets. 27553832 2017
Entrez Id: 11156
Gene Symbol: PTP4A3
PTP4A3
0.020 AlteredExpression disease BEFREE <b>Result:</b> A high PRL-3 expression level was closely correlated with unfavorable OS and PFS for glioblastoma patients, and was also significantly correlated with Ki-67 expression. 29556339 2018
Entrez Id: 84868
Gene Symbol: HAVCR2
HAVCR2
0.010 Biomarker disease BEFREE <b>Results</b>: TIM-3 was enriched in glioblastoma (the most malignant glioma) and IDH-wildtype glioma. 28919992 2017
Entrez Id: 5175
Gene Symbol: PECAM1
PECAM1
0.030 AlteredExpression disease BEFREE <i>Ex vivo</i> single-cell gene expression profiling of tumors by using CD31 and α-smooth muscle actin (αSMA) as markers for endothelial cells, and pericytes and vascular smooth muscle cells (VSMCs), respectively, confirmed the predominant expression of FN, EDA+FN and EDB+FN in the vascular compartment of glioblastoma. 29158223 2018
Entrez Id: 100422943
Gene Symbol: MIR3189
MIR3189
0.020 Biomarker disease BEFREE <i>GDF15</i> is a downstream gene of <i>S100A4</i>. miR-3189 is embedded in the intron of <i>GDF15</i>-and coexpressed with it. miR-3189-3p functions to inhibit the proliferation and migration of glioblastoma cells. 29342841 2018
Entrez Id: 57827
Gene Symbol: C6orf47
C6orf47
0.010 Biomarker disease BEFREE <i>In vitro</i> cytotoxicity assay and survival studies with mouse models were performed to evaluate therapeutic potency of NG34 against glioblastoma. 29511029 2018
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.010 Biomarker disease BEFREE <i>In vitro</i>, conditioned medium from the human glioblastoma cell line U87 activates endothelial nitric oxide synthase, causes VE-cadherin- S-nitrosylation and induces hyperpermeability. 31440166 2019
Entrez Id: 6817
Gene Symbol: SULT1A1
SULT1A1
0.020 Biomarker disease BEFREE <i>In vivo</i>, PST 3.1a reduced intersegmental vessel formation and vascularization of the subintestinal plexus in zebrafish embryos and also altered pathologic angiogenesis and glioblastoma progression <i>in vivo</i>. 30817178 2019
Entrez Id: 7903
Gene Symbol: ST8SIA4
ST8SIA4
0.010 Biomarker disease BEFREE <i>In vivo</i>, PST 3.1a reduced intersegmental vessel formation and vascularization of the subintestinal plexus in zebrafish embryos and also altered pathologic angiogenesis and glioblastoma progression <i>in vivo</i>. 30817178 2019
Entrez Id: 113451
Gene Symbol: AZIN2
AZIN2
0.070 Biomarker disease BEFREE <i>MGMT</i> promoter methylated glioblastoma is likely to show less edema, high ADC, and low perfusion. 30002055 2018
Entrez Id: 339896
Gene Symbol: GADL1
GADL1
0.070 Biomarker disease BEFREE <i>MGMT</i> promoter methylated glioblastoma is likely to show less edema, high ADC, and low perfusion. 30002055 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.100 Biomarker disease BEFREE <i>NEAT1</i> depletion also inhibited GBM cell growth and invasion in the intracranial animal model.<b>Conclusions:</b> The EGFR/<i>NEAT1</i>/EZH2/β-catenin axis serves as a critical effector of tumorigenesis and progression, suggesting new therapeutic directions in glioblastoma.<i></i>. 29138341 2018
Entrez Id: 4907
Gene Symbol: NT5E
NT5E
0.050 Biomarker disease BEFREE <i>NT5E</i>/CD73 as Correlative Factor of Patient Survival and Natural Killer Cell Infiltration in Glioblastoma. 31547570 2019
Entrez Id: 706
Gene Symbol: TSPO
TSPO
0.100 Biomarker disease BEFREE <sup>18</sup>F-GE-180, a novel TSPO ligand, has shown improved binding affinity and a high target-to-background contrast in patients with glioblastoma. 31486876 2019