Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease MGD
Entrez Id: 5340
Gene Symbol: PLG
PLG
0.050 Biomarker disease BEFREE Induction of plasminogen activator by alkylating agents in a repair defective human glioblastoma cell strain. 3697974 1986
Entrez Id: 6098
Gene Symbol: ROS1
ROS1
0.100 AlteredExpression disease BEFREE Expression and rearrangement of the ROS1 gene in human glioblastoma cells. 2827175 1987
Entrez Id: 3558
Gene Symbol: IL2
IL2
0.050 Biomarker disease BEFREE T cell suppressor factor produced by human glioblastoma cells inhibits T cell proliferation in vitro and more specifically interferes with interleukin-2 (IL-2)-dependent T cell growth. 3497030 1987
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.010 AlteredExpression disease BEFREE Examination of a human glioblastoma cell line displaying a relatively stable karyotype and absence of both copies of chromosome #13 (HeRo) as well as of a SV-40 transformed subline (HeRo-SV) using analysis on the DNA and RNA level showed that both cell lines express high levels of abl, erb B, myc, and Ha-ras mRNA. 3828971 1987
Entrez Id: 2735
Gene Symbol: GLI1
GLI1
0.100 GeneticVariation disease BEFREE The molecular cloning of the gli gene from a glioblastoma illustrates the powerful analytic nature of these laboratory techniques and the investigative potential of a cloned gene. 3059215 1988
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 AlteredExpression disease BEFREE In view of the similarity to the activated viral and cellular erbB genes in the avian system, these mutated and overexpressed EGF receptors might play a role in the onset or development of human glioblastoma cells. 3380099 1988
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.100 Biomarker disease BEFREE In view of the similarity to the activated viral and cellular erbB genes in the avian system, these mutated and overexpressed EGF receptors might play a role in the onset or development of human glioblastoma cells. 3380099 1988
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker disease BEFREE Gene amplification and rearrangements are discussed through review of recent work on the N-myc gene in neuroblastoma and the epidermal growth factor receptor (EGFR) gene in glioblastoma. 3059215 1988
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE Transforming growth factor-beta 1 is a potent inducer of plasminogen activator inhibitor type-1 in human glioblastoma and carcinoma cell lines. 3262361 1988
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.100 AlteredExpression disease BEFREE Detailed delineation of an interferon-gamma-responsive element important in human HLA-DRA gene expression in a glioblastoma multiform line. 2847168 1988
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.100 Biomarker disease BEFREE The gene encoding the receptor for epidermal growth factor was amplified two- to fivefold in the human glioblastoma cell line SF268. 3263568 1988
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker disease BEFREE Amplified gene for the epidermal growth factor receptor in a human glioblastoma cell line encodes an enzymatically inactive protein. 3263568 1988
Entrez Id: 4613
Gene Symbol: MYCN
MYCN
0.080 Biomarker disease BEFREE Gene amplification and rearrangements are discussed through review of recent work on the N-myc gene in neuroblastoma and the epidermal growth factor receptor (EGFR) gene in glioblastoma. 3059215 1988
Entrez Id: 5340
Gene Symbol: PLG
PLG
0.050 Biomarker disease BEFREE Transforming growth factor-beta 1 is a potent inducer of plasminogen activator inhibitor type-1 in human glioblastoma and carcinoma cell lines. 3262361 1988
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.020 Biomarker disease BEFREE Similar to fetal brain a major IGF-II transcript of 6.0 kb was found in the glioblastoma examined. 3211366 1988
Entrez Id: 3122
Gene Symbol: HLA-DRA
HLA-DRA
0.010 AlteredExpression disease BEFREE Detailed delineation of an interferon-gamma-responsive element important in human HLA-DRA gene expression in a glioblastoma multiform line. 2847168 1988
Entrez Id: 2098
Gene Symbol: ESD
ESD
0.010 AlteredExpression disease BEFREE Using a biochemical approach (evaluation of esterase D activity) and recombinant DNA techniques (in situ and filter hybridization with specific DNA probes) a glioblastoma cell line with karyotypical nullisomy 13 was shown to contain several chromosome #13-specific sequences. 2838156 1988
Entrez Id: 7042
Gene Symbol: TGFB2
TGFB2
0.100 Biomarker disease BEFREE As mRNA for G-TsF/TGF-beta 2 was also identified in fresh surgically removed human glioblastoma tissue, G-TsF/TGF-beta 2 may also be secreted within the tumor in vivo. 2809198 1989
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.100 Biomarker disease BEFREE The coordinate expression of the genes for TGF-beta 1 and G-TsF/TGF-beta 2 in glioblastoma was not paralleled by secretion of both polypeptides as only G-TsF/TGF-beta 2 but not TGF-beta 1 was identified in supernatants of glioblastoma cells. 2809198 1989
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 AlteredExpression disease BEFREE The authors explored the relationship between EGF-R gene expression and glioblastoma cell growth in vitro and in vivo and found that this level of EGF-R gene expression did not correlate with tumor cell growth either in soft agar or in the nude mouse. 2738645 1989
Entrez Id: 7039
Gene Symbol: TGFA
TGFA
0.070 AlteredExpression disease BEFREE Preliminary histochemical observations showed that intracellular levels of transforming growth factor alpha, a putative biochemical link between these two oncogenes, were significantly higher in glioblastoma cells than in controls. 2908920 1989
Entrez Id: 5155
Gene Symbol: PDGFB
PDGFB
0.040 AlteredExpression disease BEFREE Thus the TGF-beta signal pathway does not involve activation of protein kinase C, and at least two initially distinct intracellular signaling routes lead to activation of c-sis gene expression in this glioblastoma cell line. 2655888 1989
Entrez Id: 5155
Gene Symbol: PDGFB
PDGFB
0.040 Biomarker disease BEFREE Genomic Southern blots of DNA from 7 different cultured human glioblastoma cell lines and 15 different solid human brain tumors revealed no significant change in either the gross structure or the copy number of the c-sis gene in tumor cells vs. control cells. 2585029 1989
Entrez Id: 6285
Gene Symbol: S100B
S100B
0.030 Biomarker disease BEFREE A human glioma cell line (YKG1), which was positively identified for glial fibrillary acidic (GFA) and S-100 proteins, was established from a surgical specimen of a patient with glioblastoma. 2589023 1989