| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | Biomarker | disease | BEFREE | We have studied the effects of the PDGFR inhibitor JNJ-10198409 (JNJ) and the IGF-1R inhibitor picropodophyllin (PPP) in glioblastoma cell lines as well as in primary cultures derived from patients affected by this type of tumor. | 30200644 | 2018 | ||||
|
0.090 | Biomarker | disease | BEFREE | MicroRNA-503 acts as a tumor suppressor in glioblastoma for multiple antitumor effects by targeting IGF-1R. | 24378652 | 2014 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | Unlike in the case of IFN-γ, the restoration of TAP-1 and LMP-2 by down-regulation of IGF-1 in Glioblastoma cells was not correlated to the tyrosine phosphorylation of STAT 1. | 23526983 | 2013 | ||||
|
0.090 | Biomarker | disease | BEFREE | Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression. | 20820871 | 2011 | ||||
|
0.090 | AlteredExpression | disease | BEFREE | IGF-I is also expressed at high levels in some nervous system-derived tumors, especially in glioblastoma. | 12545204 | 2002 | ||||
|
0.090 | Biomarker | disease | BEFREE | Restoration of wild-type PTEN to glioblastoma cell lines lacking functional PTEN ablates hypoxia and IGF-1 induction of HIF-1-regulated genes. | 10691731 | 2000 | ||||
|
0.090 | Biomarker | disease | BEFREE | Human glioblastoma cells were treated with or without TAM and/or IGF-I in vitro and evaluated for: viability by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenol tetrazolium bromide cleavage assay; apoptosis by histochemical analysis of nuclear morphology and 3'-OH DNA fragments; and expression of the IGF-I receptor, and the bcl-2, bcl-xL, and bax proteins by immunoblot analysis. | 9576258 | 1998 | ||||
|
0.090 | Biomarker | disease | BEFREE | We have investigated the role of the IGF-1R in the growth and tumorigenicity of rat C6 glioblastoma cells. | 8174129 | 1994 | ||||
|
0.090 | Biomarker | disease | BEFREE | These results demonstrate that the IGF-1 receptor is strictly required for the growth of T98G glioblastoma cells. | 8138595 | 1994 |