Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE This antagonism results in increased p53 activity and can also re-activates the p53 pathway and resensitize the glioblastoma cells to apoptosis. 30656973 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Impairment of IMPDH2 activity triggers nucleolar stress and growth arrest of glioblastoma cells even in the absence of functional p53. 31371825 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Alkylaminophenol Induces G1/S Phase Cell Cycle Arrest in Glioblastoma Cells Through p53 and Cyclin-Dependent Kinase Signaling Pathway. 31001122 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Temozolomide Treatment Induces lncRNA MALAT1 in an NF-κB and p53 Codependent Manner in Glioblastoma. 30940658 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Quantitative morphological tumor characteristics on post-contrast T1-weighted MRI can to a certain degree provide insights regarding Ki67 and p53 status in patients with glioblastoma. 31020343 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 GeneticVariation disease BEFREE Mean Ki-67 labeling index was 29% (range, 1.5%-80%). p53 mutation was present in 20/36 GBs (55%), whereas OLIG2 expression was positive in 29/36 GBs (80.5%). 31003026 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Specifically, targeting cellular pathways frequently altered in glioblastoma, such as the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR), the p53 and the retinoblastoma (RB) pathways, or epidermal growth factor receptor (EGFR) gene amplification or mutation, have failed to improve outcome, likely because of redundant compensatory mechanisms, insufficient target coverage related in part to the blood brain barrier, or poor tolerability and safety. 31541850 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Effects of RG7388 and radiotherapy were analyzed in p53 wild-type glioblastoma cell lines and glioma-initiating cells. 30274984 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE In this study, biotinylated PAMAM G3 dendrimers substituted with the recognized anticancer agents cyclooxygenase-2 (COX-2) inhibitor celecoxib and peroxisome proliferator-activated receptor γ (PPARγ) agonist Fmoc-L-Leucine (G3-BCL) were tested in vitro on human cell lines with different p53 status: glioblastoma (U-118 MG), normal fibroblasts (BJ) and immortalized keratinocytes (HaCaT). 31652556 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE A tumor-targeting nanomedicine carrying the p53 gene crosses the blood-brain barrier and enhances anti-PD-1 immunotherapy in mouse models of glioblastoma. 31241175 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Our recent study indicated that TSN has anti-cancer effect in glioblastoma through induction of estrogen receptor β (ERβ) and p53. 29629572 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.300 Biomarker disease BEFREE In this study, biotinylated PAMAM G3 dendrimers substituted with the recognized anticancer agents cyclooxygenase-2 (COX-2) inhibitor celecoxib and peroxisome proliferator-activated receptor γ (PPARγ) agonist Fmoc-L-Leucine (G3-BCL) were tested in vitro on human cell lines with different p53 status: glioblastoma (U-118 MG), normal fibroblasts (BJ) and immortalized keratinocytes (HaCaT). 31652556 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.300 Biomarker disease BEFREE The megameric conjugate with nimesulide was tested in vitro on three human cell lines: squamous cell carcinoma (SCC-15) and glioblastoma (U-118 MG) overexpressing cyclooxygenase-2 (COX-2), and normal skin fibroblasts (BJ). 31601050 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE To determine whether there is a threshold for the TMZ-induced DNA damage response and exploring the factors regulating the switch between p53 dependent survival and death, the glioblastoma lines LN-229 (deficient in MGMT) and LN-229MGMT (stably transfected with MGMT) were exposed to different doses of TMZ. p53 protein expression and phosphorylation levels of p-p53ser15 and p-p53ser46 were determined by Western blotting. 30925722 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Extracellular Vesicles Released by Glioblastoma Cells Stimulate Normal Astrocytes to Acquire a Tumor-Supportive Phenotype Via p53 and MYC Signaling Pathways. 30353492 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Correlation analysis of expressions of PTEN and p53 with the value obtained by magnetic resonance spectroscopy and apparent diffusion coefficient in the tumor and the tumor-adjacent area in magnetic resonance imaging for glioblastoma. 29745082 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE We used CRN2 knock-out mice for analyses as well as for crossbreeding with a Tp53/Pten knock-out glioblastoma mouse model. 31677819 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE We studied the association of immunohistochemical expression of hypoxia inducible factor-1 alpha (HIF-1α), telomerase reverse transcriptase (TERT), isocitrate dehydrogenase 1 (IDH1) and tumor protein p53 with overall survival (OS) in glioblastoma patients uniformly treated by standard of care, with adequate follow-up. 31258744 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Targeted therapy based on p53 reactivation reduces both glioblastoma cell growth and resistance to temozolomide. 31081046 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE Hairless regulates p53 target genes to exert tumor suppressive functions in glioblastoma. 30191601 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRα Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma. 30594071 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 AlteredExpression disease BEFREE Role of asparagine endopeptidase in mediating wild-type p53 inactivation of glioblastoma. 31400201 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 AlteredExpression disease BEFREE The Kaplan-Meier survival plot illustrated poor survival in glioblastoma patients with over-expressed LINC-ROR ( P=0.010) and down-regulated p53 ( P=0.002). 30852975 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 Biomarker disease BEFREE However, clear positive effects were seen in a p53 proficient glioblastoma line (U87) when the cells were grown under serum free conditions, while no effects were found in p53 deficient glioblastoma cells (U251). 29649215 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.300 AlteredExpression disease BEFREE No difference in overall survival was registered between p53 normally expressed (NE) and overexpressed (OE) glioblastoma patients (P = 0.669). 29369420 2018