Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 GeneticVariation disease BEFREE A chromosomal translocation (Tx) that interrupts the transcription of either c-Myc or Pvt 1 is the principal lesion in many B cell malignancies including Burkitt's Lymphoma (BL), AIDs-NHL, mouse plasmacytoma (Pct) and possibly multiple myeloma (MM). 9308229 1997
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 Biomarker disease BEFREE These results suggest that Burkitt lymphoma cell lines may be deficient in an unidentified factor that recruits the machinery necessary for A:T mutation or that AID-mediated cytosine deamination in these cells may be processed by conventional base excision repair truncating somatic hypermutation at the G:C phase. 17240451 2007
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 Biomarker disease BEFREE This observation verifies that overexpression of AID in non hypermutating BL cell lines as well as the expression of endogenous AID in the hypermutating BL cell line Raji can overcome the target restriction of AID. 16310251 2006
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 Biomarker disease BEFREE In vivo, this could be sufficient to account for the elevated risk of BL-specific chromosomal translocations which would occur following DNA double strand breaks triggered by AID in secondary lymph nodes at the final stage of immunoglobulin gene maturation. 28360415 2017
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 Biomarker disease BEFREE Using 2 specific antibodies, here we show that the AID protein can be detected in GC centroblasts and their transformed counterpart (Burkitt lymphoma) but not in pre-GC B cells and post-GC neoplasms, including B-cell chronic lymphocytic leukemia and multiple myeloma. 15304391 2004
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 AlteredExpression disease BEFREE Expression of these genes enhances viral replication and induces germinal center (GC) B cell expansion, activation-induced cytidine deaminase (AID) expression, and c-myc translocation, which in turn predisposes to BL. 28707393 2017
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 AlteredExpression disease BEFREE We investigated the expression of AID in 15 BL cell lines by RT-PCR. 15061213 2004
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 AlteredExpression disease BEFREE As expected, AID overexpression in the human Burkitt lymphoma cell line BL70 caused hypermutation. 15593119 2005
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 AlteredExpression disease BEFREE High levels of AID cause strand bias of mutations at A versus T in Burkitt's lymphoma cells. 23399385 2013
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 AlteredExpression disease BEFREE CD40 ligand incorporated into the HIV envelope and expression of activation-induced cytidine deaminase may help explain the relationship between HIV load and Burkitt lymphoma. 20978397 2010
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 AlteredExpression disease BEFREE This is classically illustrated in Burkitt's lymphoma, which is characterized by AID-induced mutation and reciprocal translocation of the c-MYC oncogene with the IgH loci. 21831295 2011
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 AlteredExpression disease BEFREE Additionally, AID expression was seen to differ depending on NHL subtype, with the highest levels of expression seen in those who developed Burkitt's lymphoma. 18090274 2007