Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4363
Gene Symbol: ABCC1
ABCC1
0.010 AlteredExpression disease BEFREE MRP1 expressed on Burkitt's lymphoma cells was depleted by catfish egg lectin through Gb3-glycosphingolipid and enhanced cytotoxic effect of drugs. 22083453 2012
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.020 Biomarker disease BEFREE Rearrangements of c-myc and c-abl genes in tumour cells in Burkitt's lymphoma. 8408711 1993
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.020 Biomarker disease BEFREE Oligonucleotide sets that probe breakpoints of <i>IGH-BCL2</i> (immunoglobulin heavy-apoptosis regulator) in follicular lymphoma (FL), <i>MYC-IGH</i> (MYC proto-oncogene, bHLH transcription factor-immunoglobulin heavy) in Burkitt lymphoma (BL) and <i>BCR-ABL1</i> (RhoGEF and GTPase activating protein-ABL proto-oncogene 1, non-receptor tyrosine kinase) in chronic myelogenous leukemia (CML) were designed. 28515100 2017
Entrez Id: 27
Gene Symbol: ABL2
ABL2
0.010 AlteredExpression disease BEFREE In this study we evaluated ARG protein expression in Follicular Lymphoma (FL), Burkitt's Lymphoma (BL) and Diffused Large B Cell Lymphoma (DLBCL) in comparison with non-neoplastic lymph nodes. 19604504 2009
Entrez Id: 117
Gene Symbol: ADCYAP1R1
ADCYAP1R1
0.010 Biomarker disease BEFREE In addition, PAC-1 was probably known to be associated with Burkitt Lymphoma (Odds Ratio [OR] 6.67, Relative Risk [RR] 3.13, 95% CI 1.06-9.21; p = 0.02). 31326577 2019
Entrez Id: 30817
Gene Symbol: ADGRE2
ADGRE2
0.010 AlteredExpression disease BEFREE Based on this multi-omics analysis we identified ADGRE5 (alias CD97) - a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors - as a MYC target gene, which is specifically expressed in BL but not in DLBCL regardless of MYC translocation. 30953469 2019
Entrez Id: 976
Gene Symbol: ADGRE5
ADGRE5
0.010 Biomarker disease BEFREE Since ADGRE5 plays an important role in tumor cell formation, metastasis and invasion, it might also be instrumental to better understand the different pathobiology of BL and DLBCL and help to explain discrepant clinical characteristics of BL and DLBCL. 30953469 2019
Entrez Id: 27161
Gene Symbol: AGO2
AGO2
0.010 Biomarker disease BEFREE A comparison of AGO2-IP-enriched genes in primary BL cases with BL cell lines indicated that despite a considerable overlap, the miRNA targetomes of BL cell lines show substantial differences with the targetomes of primary BL tumors. 29458013 2018
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 Biomarker disease BEFREE These results suggest that Burkitt lymphoma cell lines may be deficient in an unidentified factor that recruits the machinery necessary for A:T mutation or that AID-mediated cytosine deamination in these cells may be processed by conventional base excision repair truncating somatic hypermutation at the G:C phase. 17240451 2007
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 AlteredExpression disease BEFREE Expression of these genes enhances viral replication and induces germinal center (GC) B cell expansion, activation-induced cytidine deaminase (AID) expression, and c-myc translocation, which in turn predisposes to BL. 28707393 2017
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 AlteredExpression disease BEFREE We investigated the expression of AID in 15 BL cell lines by RT-PCR. 15061213 2004
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 AlteredExpression disease BEFREE As expected, AID overexpression in the human Burkitt lymphoma cell line BL70 caused hypermutation. 15593119 2005
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 GeneticVariation disease BEFREE A chromosomal translocation (Tx) that interrupts the transcription of either c-Myc or Pvt 1 is the principal lesion in many B cell malignancies including Burkitt's Lymphoma (BL), AIDs-NHL, mouse plasmacytoma (Pct) and possibly multiple myeloma (MM). 9308229 1997
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 AlteredExpression disease BEFREE High levels of AID cause strand bias of mutations at A versus T in Burkitt's lymphoma cells. 23399385 2013
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 Biomarker disease BEFREE This observation verifies that overexpression of AID in non hypermutating BL cell lines as well as the expression of endogenous AID in the hypermutating BL cell line Raji can overcome the target restriction of AID. 16310251 2006
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 Biomarker disease BEFREE In vivo, this could be sufficient to account for the elevated risk of BL-specific chromosomal translocations which would occur following DNA double strand breaks triggered by AID in secondary lymph nodes at the final stage of immunoglobulin gene maturation. 28360415 2017
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 AlteredExpression disease BEFREE CD40 ligand incorporated into the HIV envelope and expression of activation-induced cytidine deaminase may help explain the relationship between HIV load and Burkitt lymphoma. 20978397 2010
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 AlteredExpression disease BEFREE This is classically illustrated in Burkitt's lymphoma, which is characterized by AID-induced mutation and reciprocal translocation of the c-MYC oncogene with the IgH loci. 21831295 2011
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 Biomarker disease BEFREE Using 2 specific antibodies, here we show that the AID protein can be detected in GC centroblasts and their transformed counterpart (Burkitt lymphoma) but not in pre-GC B cells and post-GC neoplasms, including B-cell chronic lymphocytic leukemia and multiple myeloma. 15304391 2004
Entrez Id: 57379
Gene Symbol: AICDA
AICDA
0.100 AlteredExpression disease BEFREE Additionally, AID expression was seen to differ depending on NHL subtype, with the highest levels of expression seen in those who developed Burkitt's lymphoma. 18090274 2007
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.080 AlteredExpression disease BEFREE These corroborated the upregulation of PIK3AP1 and AKT activation in BJAB cells expressing high levels of both EBERs and EBNA1 (a surrogate of Burkitt's lymphoma EBV latency I) relative to those expressing only EBNA1. 26121143 2015
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.080 AlteredExpression disease BEFREE Recurrent FOXO1 mutations, which prevent AKT targeting and lock the transcription factor in the nucleus, are used by BL to circumvent mutual exclusivity between PI3K and FOXO1 activation. 30333121 2018
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.080 Biomarker disease BEFREE We further demonstrated that the blockage of radiation-induced activation of the PI3K/AKT pathway and its downstream regulator NF-κB by either curcumin or specific PI3/AKT inhibitors (LY294002 for PI3K or SH-5 for AKT) enhance apoptosis in three human Burkitt's lymphoma cell lines (Namalwa, Ramos, and Raji) that were treated with ionizing radiation. 23603894 2013
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.080 Biomarker disease BEFREE Moreover, hyper-activation of the PI3K-AKT pathway by overexpression of a constitutively active version of AKT (myrAKT) or knockdown of PTEN repressed the growth of BL cell lines. 31719683 2020
Entrez Id: 207
Gene Symbol: AKT1
AKT1
0.080 Biomarker disease BEFREE Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma. 28619753 2017