Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE As additional antisense molecules targeting oncogenes involved in lymphomas become available, it will be possible to combine them with AO to enhance their efficacy, either targeting the same gene at two sites or more a combination of genes (for example, BCL-2 and MYC in Burkitt's lymphoma). 9378470 1997
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE Oncogenic MYC activation promotes proliferation in Burkitt lymphoma, but also induces cell-cycle arrest and apoptosis mediated by p53, a tumor suppressor that is mutated in 40% of Burkitt lymphoma cases. 31000522 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE This facilitates survival of eBL tumor cells with the IGH/MYC chromosomal translocation and promotes MYC-induced cell cycle progression, initiating eBL lymphomagenesis. 29132323 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE We analyzed 74 adult gray zone and 10 reference pediatric BL using immunohistochemistry (Ki-67, CD10, bcl2, bcl6) and fluorescence in situ hybridization (FISH) for MYC, BCL2, and BCL6 breakpoints. 16006805 2005
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE All cases showed morphologic and immunophenotypic features of Burkitt lymphoma with MYC rearrangement in all 5 cases tested. 27257042 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Novel genomic imbalances and chromosome translocations involving c-myc gene in Burkitt's lymphoma. 11587216 2001
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE The different types of C-MYC translocation reported in BL may also be related to the different stages of B-cell maturation. 15840698 2005
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE Truncation does not abrogate transcriptional downregulation of the c-myc gene by sodium butyrate in Burkitt's lymphoma cells. 3691477 1987
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE The upregulation or mutation of C-MYC has been observed in gastric, colon, breast, and lung tumors and in Burkitt's lymphoma. 20737197 2010
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE Opposite replication polarity of the germ line c-myc gene in HeLa cells compared with that of two Burkitt lymphoma cell lines. 2710118 1989
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE MYC dysregulation needs other cooperating events for BL development. 26887776 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE DLCL with c-MYC/IGH shares clinical features with sBL but is characterized further by an older age distribution. 10653866 2000
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE We have examined the position of the chromosomal breakpoint relative to the human c-myc gene (MYC) and the presence of other structural alterations of the same locus in 19 fresh samples of Burkitt lymphoma (BL) and 13 BL-derived cell lines. 3458257 1986
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Deregulated c-myc expression, as a consequence of translocation of the c-myc gene to one of the immunoglobulin loci, appears to play an important role in the pathogenesis of several B-cell tumors, including Burkitt's lymphoma, mouse plasmacytoma and rat immunocytoma. 1563831 1992
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE We found that the most 3' enhancer region (MHS4) activated the c-myc promoter by 46-fold in the Raji Burkitt's lymphoma cell line, and it was the most active enhancer in these cells. 10931834 2000
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Cytogenetic MYC alterations aid in differentiating diffuse large B-cell lymphoma (DLBCL) from Burkitt lymphoma. 22314191 2012
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Burkitt lymphoma (BL) is an aggressive B cell lymphoma characterized by the reciprocal translocation of the c-Myc gene with immunoglobulin genes. 27044389 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE We have analyzed the type of MYC/IG heavy-chain locus (IGH) rearrangement present in 15 patients affected by t(8;14)-positive primary Burkitt's lymphoma or acute lymphoblastic leukemia of the L3 type in an attempt to map in detail the locations of the chromosome 8 and chromosome 14 breakpoints. 7691153 1993
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE A high Ki-67 proliferation index and positive bcl-2 staining (on cytospin slides or cell block material) of cases not conforming to typical Burkitt lymphoma morphology should prompt FISH analysis for c-MYC and/or IGH-BCL2 rearrangements to identify DHL, particularly if tissue biopsy is not expected. 21560252 2011
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE A new algorithm discriminating BL from DLBCL emerged, including the expression of CSE1L, STAT3, and MYC translocation. 22967991 2013
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE In the Burkitt's lymphoma (BL) cell line BL67 the first exon of the c-myc gene is fused to the mu-switch region of the immunoglobulin heavy-chain gene (IgH). 1620543 1992
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Chromosomal translocations involving MYC at 8q24 are found in Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), and B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and BL (BCLU). 22018272 2011
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE Here, we report sAJM589, a novel small molecule Myc inhibitor, identified from a PCA-based high-throughput screen. sAJM589 potently disrupts the Myc-Max heterodimer in a dose dependent manner with an IC<sub>50</sub> of 1.8 ± 0.03 μM. sAJM589 preferentially inhibits transcription of Myc target genes in a Burkitt lymphoma cell model, P493-6. 28976731 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Burkitt lymphoma and a subset of diffuse large B-cell lymphomas are characterized by chromosomal alterations affecting the MYC oncogene on 8q24. 22120970 2012
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE Collectively, our data provide evidence that c-MYC directly regulates GLI1 and support an antiapoptotic role for GLI1 in Burkitt lymphoma. 23525267 2013