Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. 6818551 1982
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE We have determined the sequence of the normal human c-myc gene and compared it to portions of a c-myc gene that has been translocated into the immunoglobulin heavy chain locus in a Burkitt lymphoma cell. 6414718 1983
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE The breakpoint on human chromosome 8 may therefore also differ in different Burkitt lymphoma cell lines, because we have observed DNA rearrangement of the c-myc gene with the C(mu) gene in only some of the Burkitt lymphoma cell lines studied elsewhere. 6402776 1983
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE Recombinant DNA clones have been used to directly demonstrate that the Burkitt lymphoma cell line Raji, t(8;14) (q24;q32), has a rearranged copy of the c-myc gene adjacent to the gamma 1 constant region gene of the human immunoglobulin heavy-chain locus; the genes are arranged in the opposite direction for transcription. 6306472 1983
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 PosttranslationalModification disease BEFREE Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma. 6419122 1984
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE These results support a model in which c-myc oncogene activation in Burkitt's lymphoma occurs by disruption of a normal transcriptional control mechanism in which the c-myc protein is itself involved. 6547209 1984
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE Our present data fit into the concept that in all Burkitt lymphoma lines investigated so far, including cases with t(8;14) and the variant translocations t(2;8) and t(8;22), the c-myc gene becomes situated at the 5' side of an immunoglobulin constant gene. 6441706 1984
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE The translocated c-myc gene in AW-Ramos, a Burkitt lymphoma cell line carrying the 8;14 translocation, is expressed at 2- to 5-fold higher levels than c-myc in lymphoblastoid cell lines. 6593728 1984
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 PosttranslationalModification disease BEFREE Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in Burkitt lymphoma. 6327064 1984
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE If similar enhancers exist in humans they may lead to increased transcription of the translocated c-myc gene and thus contribute to oncogenesis in Burkitt lymphoma. 6419124 1984
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE A novel alteration in the structure of an activated c-myc gene in a variant t(2;8) Burkitt lymphoma. 6327071 1984
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE In particular, the c-myc gene is translocated in Burkitt's lymphoma and is amplified in the human promyelocytic leukaemia cell line, HL-60, which contains double minute chromosomes (DMs). 6646201 1984
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE We have cloned and sequenced the translocated c-myc gene from the Burkitt's lymphoma CA46 cell line that carries a reciprocal translocation between chromosomes 8 and 14. 3921823 1985
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE BL67 and BL18 are Burkitt's lymphoma cell lines with t(8;14) translocations (the breakpoint is in the first exon and first intron, respectively) in which the mu-heavy chain switch region is fused to the c-myc gene in head to head orientation. 3004968 1985
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE We have examined the position of the chromosomal breakpoint relative to the human c-myc gene (MYC) and the presence of other structural alterations of the same locus in 19 fresh samples of Burkitt lymphoma (BL) and 13 BL-derived cell lines. 3458257 1986
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE The regular juxtaposition of the c-myc gene to one of the three immunoglobulin loci in Burkitt's lymphoma, mouse plasmacytoma, and rat immunocytoma is a case in point. 3011242 1986
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE These results suggest that translocations t(8;14) involving TcR-alpha and c-myc genes in T-cell malignancies are analogous to variant t(2;8) and t(8;22) translocations observed in Burkitt lymphoma. 3466870 1986
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE Truncation does not abrogate transcriptional downregulation of the c-myc gene by sodium butyrate in Burkitt's lymphoma cells. 3691477 1987
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation disease BEFREE We analyzed the Burkitt's lymphoma line BL64 in which a reciprocal translocation joins the immunoglobulin kappa light-chain locus on chromosome 2 to the c-myc gene on chromosome 8. 3110600 1987
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE We have cloned the translocation-associated MYC gene from the Burkitt lymphoma cell line (BL2) with a t(8;22) chromosomal translocation and have determined the nucleotide sequence of the first exon and of the 3' and 5' flanking regions, where sequences with putative regulatory functions have been identified. 3033665 1987
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE By utilizing an EBV-negative BL (BJAB) and several EBV-positive sublines derived from it by in vitro infection, it was possible to show that the presence of the virus was associated with altered expression and copy number of MYC. 3039510 1987
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE Opposite replication polarity of the germ line c-myc gene in HeLa cells compared with that of two Burkitt lymphoma cell lines. 2710118 1989
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 AlteredExpression disease BEFREE Chromosome rearrangements that break in or near MYC can result in altered expression of this gene and are thought to be a primary change leading to the transformed phenotype in certain neoplastic diseases, particularly Burkitt lymphoma. 2914707 1989
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE Some of the translocations that occur downstream of MYC in Burkitt lymphoma transect PVT; others lie between the two genes. 2470097 1989
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 Biomarker disease BEFREE This alteration in stability of MYC transcripts was reversibly associated with the presence of the virus, since an EBV-negative revertant BJAB line did not display an increase in stability of MYC transcripts in late exponential phase of growth. 2551670 1989